Browsing Theses by Subject "insulin"
Now showing items 1-4 of 4
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Acute Regulation of Na+-K+-ATPase Activity in Skeletal Muscles of Different Fibre Type Composition in Response to Insulin Exposure
(University of Waterloo, 2008-01-09)The Na+-K+-ATPase (pump) is a transmembrane, multi-subunit (α and β) protein that is expressed in all cells, and particularly in skeletal muscle cells. In one cycle, it pumps 3 Na+ ions out of the cell and 2 K+ ions into ... -
The associations between insulin, hypoglycemia, and dementia: Combating threats to internal validity in a series of population-based cohort studies
(University of Waterloo, 2023-05-01)Although the association between type 2 diabetes and dementia is recognized, findings from the epidemiology literature on the effect of insulin and one of its side effects, hypoglycemia, are less clear. The currently ... -
Glucose Metabolism in High-Risk Prostate Cancer Patients throughout the Acute Disease Trajectory
(University of Waterloo, 2016-05-16)Background: Hyperglycemia and insulin resistance are associated with obesity, physical inactivity, and poor diet, and may be related to hyperinsulinemia, disrupted lipid and adipokine signaling, and pro-inflammation. The ... -
ROLE OF SECOND MESSENGER SIGNALING PATHWAYS IN THE REGULATION OF SARCOPLASMIC RETICULUM CALCIUM-HANDLING PROPERTIES IN THE LEFT VENTRICLE AND SKELETAL MUSCLES OF DIFFERENT FIBRE TYPE COMPOSITION
(University of Waterloo, 2007-02-09)The overall objective of this thesis was to examine mechanisms involved in the acute regulation of sarcoplasmic reticulum (SR) Ca2+-handling properties by second messenger signaling pathways in skeletal and cardiac muscle. ...