Browsing Theses by Subject "diabetes"
Now showing items 1-6 of 6
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The associations between insulin, hypoglycemia, and dementia: Combating threats to internal validity in a series of population-based cohort studies
(University of Waterloo, 2023-05-01)Although the association between type 2 diabetes and dementia is recognized, findings from the epidemiology literature on the effect of insulin and one of its side effects, hypoglycemia, are less clear. The currently ... -
Characterization of Changes in the Kidney, Liver, and Adipose Tissue of RTSAKO Mice
(University of Waterloo, 2018-11-02)Our laboratory has developed a novel genetic mouse model with kidney-specific lipid accumulation called RTSAKOs. The principle aim of my thesis was to study differences in the expression of genes and proteins related to ... -
Does sex or exercise modality influence post-exercise glucose handling or insulin sensitivity?
(University of Waterloo, 2022-09-20)Exercise has long been recognized for its beneficial effects on glucose handling in both insulin sensitive and insulin resistant populations. However, there is conflicting evidence in regards to the best type and duration ... -
Effects of high-fat feeding on skeletal muscle insulin signalling in sarcolipin knockout mice
(University of Waterloo, 2010-08-26)Type II diabetes mellitus (T2DM) has been associated with the onset of diet-induced obesity, which is currently on the rise worldwide. T2DM is typically characterized by insulin resistance in peripheral tissues such as ... -
Mathematical Models of Mitochondria in the Kidney and Liver
(University of Waterloo, 2022-03-24)Mitochondria are key players in several kinds of tissue injury, and are even the site of mechanism of certain diseases. In this work we introduce new models of mitochondrial ATP generation in multiple tissues, including ... -
Sex and Gender, Socioeconomic Status, and Type 2 Diabetes Mellitus
(University of Waterloo, 2021-09-21)Background: Diabetes mellitus imposes challenges on health care systems, economies, and the individuals living with and at risk for this illness. Diabetes is a major chronic disease and affects more and more Canadians each ...