Direct, oxidative halogenation of diaryl- or dialkylphosphine oxides with (dihaloiodo)arenes
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Date
2018-08
Authors
ELJO, JASMIN
Murphy, Graham K.
Advisor
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
The oxidative halogenation of diaryl- or dialkylphosphine oxides with the hypervalent iodine reagents (difluoroiodo)toluene (p-TolIF2, 1) and (dichloroiodo)benzene (PhICl2, 2) is reported. Phosphoric fluorides could be recovered in 32–75% yield, or they could be trapped with EtOH to give the corresponding phosphinate in typically good yield. Phosphoric chlorides were not readily isolable, and were trapped with alcohol and amine nucleophiles, giving diaryl- or dialkylphos-phinates and phosphinamides in up to 90% yield.
Description
Keywords
phosphoric chloride, phosphoric fluoride, hypervalent iodine, phosphinate, phosphinamide