Show simple item record

dc.contributor.authorBrown, Ronald B.
dc.contributor.authorRazzaque, Mohammed S. 15:33:58 (GMT) 15:33:58 (GMT)
dc.descriptionThe final publication is available at Elsevier via © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
dc.description.abstractIn this article, we briefly summarized evidence that cellular phosphate burden from phosphate toxicity is a pathophysiological determinant of cancer cell growth. Tumor cells express more phosphate cotransporters and store more inorganic phosphate than normal cells, and dysregulated phosphate homeostasis is associated with the genesis of various human tumors. High dietary phosphate consumption causes the growth of lung and skin tumors in experimental animal models. Additional studies show that excessive phosphate burden induces growth-promoting cell signaling, stimulates neovascularization, and is associated with chromosome instability and metastasis. Studies have also shown phosphate is a mitogenic factor that affects various tumor cell growth. Among epidemiological evidence linking phosphate and tumor formation, the Health Professionals Follow-Up Study found that high dietary phosphate levels were independently associated with lethal and high-grade prostate cancer. Further research is needed to determine how excessive dietary phosphate consumption influences initiation and promotion of tumorigenesis, and to elucidate prognostic benefits of reducing phosphate burden to decrease tumor cell growth and delay metastatic progression. The results of such studies could provide the basis for therapeutic modulation of phosphate metabolism for improved patient outcome.en
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.subjectPhosphate toxicityen
dc.titlePhosphate toxicity and tumorigenesisen
dcterms.bibliographicCitationBrown, R. B., & Razzaque, M. S. (2018). Phosphate toxicity and tumorigenesis. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1869(2), 303–309.
uws.contributor.affiliation1Faculty of Applied Health Sciencesen
uws.contributor.affiliation2Public Health and Health Systems (School of)en

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International


University of Waterloo Library
200 University Avenue West
Waterloo, Ontario, Canada N2L 3G1
519 888 4883

All items in UWSpace are protected by copyright, with all rights reserved.

DSpace software

Service outages