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dc.contributor.authorBoyaci, Ezel
dc.contributor.authorGómez-Ríos, Germán Augusto
dc.contributor.authorPawliszyn, Janusz
dc.contributor.authorPoole, Justen J.
dc.contributor.authorTascon, Marcos
dc.contributor.authorReyes-Garcés, Nathaly 19:39:22 (GMT) 19:39:22 (GMT)
dc.description.abstractThis study demonstrates the quantitative capabilities of coated blade spray (CBS) mass spectrometry (MS) for the concomitant analysis of multiple target substances in biofluid spots. In CBS-MS the analytes present in a given sample are first isolated and enriched in the thin coating of the CBS device. After a quick rinsing of the blade surface, as to remove remaining matrix, the analytes are quickly desorbed with the help of a solvent and then directly electrosprayed into the MS analyzer. Diverse pain management drugs, controlled substances, and therapeutic medications were successfully determined using only 10 µL of biofluid, with limits of quantitation in the low/sub ng·mL−1 level attained within 7 minutes.en
dc.description.sponsorshipThermo Scientific Natural Sciences and Engineering Research Council (NSERC) of Canada - Industrial Research Chair program Authors are very grateful with Pfizer Canada Inc., Merck Canada Inc., Quebec Consortium for Drug Discovery (CQDM), Brain Canada, and Ontario Brain Institute for the grant “Solid phase microextraction-based integrated platform for untargeted and targeted in vivo brain studies.en
dc.publisherSpringer Natureen
dc.rightsAttribution 4.0 International*
dc.subjectBioanalytical chemistryen
dc.subjectLaboratory techniques and proceduresen
dc.subjectPain managementen
dc.titleQuantitative analysis of biofluid spots by coated blade spray mass spectrometry, a new approach to rapid screeningen
dcterms.bibliographicCitationBoyacı, E., Gómez-Ríos, G. A., Pawliszyn, J., Poole, J., Tascon, M., & Reyes-Garcés, N. (2017). Quantitative analysis of biofluid spots by coated blade spray mass spectrometry, a new approach to rapid screening. Scientific Reports, 7(1), 16104.
uws.contributor.affiliation1Faculty of Scienceen

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