Quantitative analysis of biofluid spots by coated blade spray mass spectrometry, a new approach to rapid screening
dc.contributor.author | Boyaci, Ezel | |
dc.contributor.author | Gómez-Ríos, Germán Augusto | |
dc.contributor.author | Pawliszyn, Janusz | |
dc.contributor.author | Poole, Justen J. | |
dc.contributor.author | Tascon, Marcos | |
dc.contributor.author | Reyes-Garcés, Nathaly | |
dc.date.accessioned | 2017-11-24T19:39:22Z | |
dc.date.available | 2017-11-24T19:39:22Z | |
dc.date.issued | 2017-11-23 | |
dc.description.abstract | This study demonstrates the quantitative capabilities of coated blade spray (CBS) mass spectrometry (MS) for the concomitant analysis of multiple target substances in biofluid spots. In CBS-MS the analytes present in a given sample are first isolated and enriched in the thin coating of the CBS device. After a quick rinsing of the blade surface, as to remove remaining matrix, the analytes are quickly desorbed with the help of a solvent and then directly electrosprayed into the MS analyzer. Diverse pain management drugs, controlled substances, and therapeutic medications were successfully determined using only 10 µL of biofluid, with limits of quantitation in the low/sub ng·mL−1 level attained within 7 minutes. | en |
dc.description.sponsorship | Thermo Scientific Natural Sciences and Engineering Research Council (NSERC) of Canada - Industrial Research Chair program Authors are very grateful with Pfizer Canada Inc., Merck Canada Inc., Quebec Consortium for Drug Discovery (CQDM), Brain Canada, and Ontario Brain Institute for the grant “Solid phase microextraction-based integrated platform for untargeted and targeted in vivo brain studies. | en |
dc.identifier.uri | https://doi.org/10.1038/s41598-017-16494-z | |
dc.identifier.uri | http://hdl.handle.net/10012/12667 | |
dc.language.iso | en | en |
dc.publisher | Springer Nature | en |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Bioanalytical chemistry | en |
dc.subject | Laboratory techniques and procedures | en |
dc.subject | Pain management | en |
dc.title | Quantitative analysis of biofluid spots by coated blade spray mass spectrometry, a new approach to rapid screening | en |
dc.type | Article | en |
dcterms.bibliographicCitation | Boyacı, E., Gómez-Ríos, G. A., Pawliszyn, J., Poole, J., Tascon, M., & Reyes-Garcés, N. (2017). Quantitative analysis of biofluid spots by coated blade spray mass spectrometry, a new approach to rapid screening. Scientific Reports, 7(1), 16104. https://doi.org/10.1038/s41598-017-16494-z | en |
uws.contributor.affiliation1 | Faculty of Science | en |
uws.contributor.affiliation2 | Chemistry | en |
uws.peerReviewStatus | Reviewed | en |
uws.scholarLevel | Faculty | en |
uws.typeOfResource | Text | en |
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