Quantitative analysis of biofluid spots by coated blade spray mass spectrometry, a new approach to rapid screening

Simple item page
dc.contributor.authorBoyaci, Ezel
dc.contributor.authorGómez-Ríos, Germán Augusto
dc.contributor.authorPawliszyn, Janusz
dc.contributor.authorPoole, Justen J.
dc.contributor.authorTascon, Marcos
dc.contributor.authorReyes-Garcés, Nathaly
dc.date.accessioned2017-11-24T19:39:22Z
dc.date.available2017-11-24T19:39:22Z
dc.date.issued2017-11-23
dc.description.abstractThis study demonstrates the quantitative capabilities of coated blade spray (CBS) mass spectrometry (MS) for the concomitant analysis of multiple target substances in biofluid spots. In CBS-MS the analytes present in a given sample are first isolated and enriched in the thin coating of the CBS device. After a quick rinsing of the blade surface, as to remove remaining matrix, the analytes are quickly desorbed with the help of a solvent and then directly electrosprayed into the MS analyzer. Diverse pain management drugs, controlled substances, and therapeutic medications were successfully determined using only 10 µL of biofluid, with limits of quantitation in the low/sub ng·mL−1 level attained within 7 minutes.en
dc.description.sponsorshipThermo Scientific Natural Sciences and Engineering Research Council (NSERC) of Canada - Industrial Research Chair program Authors are very grateful with Pfizer Canada Inc., Merck Canada Inc., Quebec Consortium for Drug Discovery (CQDM), Brain Canada, and Ontario Brain Institute for the grant “Solid phase microextraction-based integrated platform for untargeted and targeted in vivo brain studies.en
dc.identifier.urihttps://doi.org/10.1038/s41598-017-16494-z
dc.identifier.urihttp://hdl.handle.net/10012/12667
dc.language.isoenen
dc.publisherSpringer Natureen
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectBioanalytical chemistryen
dc.subjectLaboratory techniques and proceduresen
dc.subjectPain managementen
dc.titleQuantitative analysis of biofluid spots by coated blade spray mass spectrometry, a new approach to rapid screeningen
dc.typeArticleen
dcterms.bibliographicCitationBoyacı, E., Gómez-Ríos, G. A., Pawliszyn, J., Poole, J., Tascon, M., & Reyes-Garcés, N. (2017). Quantitative analysis of biofluid spots by coated blade spray mass spectrometry, a new approach to rapid screening. Scientific Reports, 7(1), 16104. https://doi.org/10.1038/s41598-017-16494-zen
uws.contributor.affiliation1Faculty of Scienceen
uws.contributor.affiliation2Chemistryen
uws.peerReviewStatusRevieweden
uws.scholarLevelFacultyen
uws.typeOfResourceTexten

Files

Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
Boyacı et al. - 2017 - Quantitative analysis of biofluid spots by coated .pdf
Size:
2.11 MB
Format:
Adobe Portable Document Format
Description:
Publisher's version
Download
No Thumbnail Available
Name:
41598_2017_16494_MOESM1_ESM.doc
Size:
146 KB
Format:
Microsoft Word
Description:
Supplemental Information
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
6.08 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Waterloo Research
Chemistry