Fast Quantitation of Target Analytes in Small Volumes of Complex Samples by Matrix-Compatible Solid-Phase Microextraction Devices
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Date
2017-06-20
Authors
Piri-Moghadam, Hamed
Ahmadi, Fardin
Reyes-Garcés, Nathaly
Boyaci, Ezel
Reyes-Garces, Nathaly
Aghakhani, Ali
Bojko, Barbara
Pawliszyn, Janusz
Advisor
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Journal ISSN
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Publisher
Wiley
Abstract
Herein we report the development of solid-phase microextraction (SPME) devices designed to perform fast extraction/enrichment of target analytes present in small volumes of complex matrices (i.e. V <= 10 mu L). Micro-sampling was performed with the use of etched metal tips coated with a thin layer of biocompatible nano-structured polypyrrole (PPy), or by using coated blade spray (CBS) devices. These devices can be coupled either to liquid chromatography (LC), or directly to mass spectrometry (MS) via dedicated interfaces. The reported results demonstrated that the whole analytical procedure can be carried out within a few minutes with high sensitivity and quantitation precision, and can be used to sample from various biological matrices such as blood, urine, or Allium cepa L single-cells.
Description
This is the peer reviewed version of the following article: Piri-Moghadam, H., Ahmadi, F., Gómez-Ríos, G. A., Boyacı, E., Reyes-Garcés, N., Aghakhani, A., … Pawliszyn, J. (2016). Fast Quantitation of Target Analytes in Small Volumes of Complex Samples by Matrix-Compatible Solid-Phase Microextraction Devices. Angewandte Chemie International Edition, 55(26), 7510–7514., which has been published in final form at https://doi.org/10.1002/anie.201601476. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Keywords
coated blade spray, mass spectrometry, small volumes, solid-phase microextraction (SPME), trace analysis