Show simple item record

dc.contributor.authorTaylor, Robert
dc.contributor.authorScott, Bradley
dc.contributor.authorTaylor, Scott D.
dc.contributor.authorPalmer, Michael 17:24:50 (GMT) 17:24:50 (GMT)
dc.descriptionThis document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publi-cation in ACS Infectious Diseases,© American Chemical Society after peer review. To access the final edited and published work see
dc.description.abstractThe lipopeptide antibiotic daptomycin is active against Gram-positive pathogens. It permeabilizes bacterial cell membranes, which involves the formation of membrane-associated oligomers. We here studied a dimer of daptomycin whose two subunits were linked through a bivalent aliphatic acyl chain. Unexpectedly, the dimer had very low activity on vegetative Staphylococcus aureus and Bacillus subtilis cells. However, activity resembled that of monomeric daptomycin on liposomes and on B. subtilis L-forms. These findings underscore the importance of the bacterial cell wall in daptomycin resistance.en
dc.description.sponsorshipNSERC operating grants to M.P. (250265-2013) and S.T. (155283-2012).en
dc.publisherAmerican Chemical Societyen
dc.subjectAntiobiotic resistanceen
dc.subjectBacterial L-formsen
dc.subjectCell wall permeabilityen
dc.subjectLipopeptide antibioticsen
dc.titleAn Acyl-Linked Dimer of Daptomycin Is Strongly Inhibited by the Bacterial Cell Wallen
dcterms.bibliographicCitationTaylor, R. M., Scott, B., Taylor, S., & Palmer, M. (2017). An Acyl-Linked Dimer of Daptomycin Is Strongly Inhibited by the Bacterial Cell Wall. ACS Infectious Diseases.
uws.contributor.affiliation1Faculty of Scienceen

Files in this item


This item appears in the following Collection(s)

Show simple item record


University of Waterloo Library
200 University Avenue West
Waterloo, Ontario, Canada N2L 3G1
519 888 4883

All items in UWSpace are protected by copyright, with all rights reserved.

DSpace software

Service outages