An Acyl-Linked Dimer of Daptomycin Is Strongly Inhibited by the Bacterial Cell Wall

dc.contributor.authorTaylor, Robert
dc.contributor.authorScott, Bradley
dc.contributor.authorTaylor, Scott D.
dc.contributor.authorPalmer, Michael
dc.date.accessioned2017-04-13T17:24:50Z
dc.date.available2017-04-13T17:24:50Z
dc.date.issued2017-03-28
dc.descriptionThis document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publi-cation in ACS Infectious Diseases,© American Chemical Society after peer review. To access the final edited and published work see http://pubs.acs.org/doi/full/10.1021/acsinfecdis.7b00019.en
dc.description.abstractThe lipopeptide antibiotic daptomycin is active against Gram-positive pathogens. It permeabilizes bacterial cell membranes, which involves the formation of membrane-associated oligomers. We here studied a dimer of daptomycin whose two subunits were linked through a bivalent aliphatic acyl chain. Unexpectedly, the dimer had very low activity on vegetative Staphylococcus aureus and Bacillus subtilis cells. However, activity resembled that of monomeric daptomycin on liposomes and on B. subtilis L-forms. These findings underscore the importance of the bacterial cell wall in daptomycin resistance.en
dc.description.sponsorshipNSERC operating grants to M.P. (250265-2013) and S.T. (155283-2012).en
dc.identifier.urihttps://doi.org/10.1021/acsinfecdis.7b00019
dc.identifier.urihttp://hdl.handle.net/10012/11662
dc.language.isoenen
dc.publisherAmerican Chemical Societyen
dc.subjectAntiobiotic resistanceen
dc.subjectBacterial L-formsen
dc.subjectCell wall permeabilityen
dc.subjectLipopeptide antibioticsen
dc.titleAn Acyl-Linked Dimer of Daptomycin Is Strongly Inhibited by the Bacterial Cell Wallen
dc.typeArticleen
dcterms.bibliographicCitationTaylor, R. M., Scott, B., Taylor, S., & Palmer, M. (2017). An Acyl-Linked Dimer of Daptomycin Is Strongly Inhibited by the Bacterial Cell Wall. ACS Infectious Diseases. https://doi.org/10.1021/acsinfecdis.7b00019en
uws.contributor.affiliation1Faculty of Scienceen
uws.contributor.affiliation2Chemistryen
uws.peerReviewStatusRevieweden
uws.scholarLevelFacultyen
uws.typeOfResourceTexten

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