An Acyl-Linked Dimer of Daptomycin Is Strongly Inhibited by the Bacterial Cell Wall
Abstract
The lipopeptide antibiotic daptomycin is active against Gram-positive pathogens. It permeabilizes bacterial cell membranes, which involves the formation of membrane-associated oligomers. We here studied a dimer of daptomycin whose two subunits were linked through a bivalent aliphatic acyl chain. Unexpectedly, the dimer had very low activity on vegetative Staphylococcus aureus and Bacillus subtilis cells. However, activity resembled that of monomeric daptomycin on liposomes and on B. subtilis L-forms. These findings underscore the importance of the bacterial cell wall in daptomycin resistance.
Collections
Cite this version of the work
Robert Taylor, Bradley Scott, Scott D. Taylor, Michael Palmer
(2017).
An Acyl-Linked Dimer of Daptomycin Is Strongly Inhibited by the Bacterial Cell Wall. UWSpace.
http://hdl.handle.net/10012/11662
Other formats