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The group trend of lanthanides binding to DNA and DNAzymes with a complex but symmetric pattern

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Liu_Juewen(15).pdf (725.44 KB)

Date

2014-07-18

Authors

Lin, Wei Ting David
Huang, Po-Jung Jimmy
Pautler, Rachel
Liu, Juewen

Journal Title

Journal ISSN

Volume Title

Publisher

Royal Society of Chemistry

Abstract

Using sensitized Tb3+ luminescence spectroscopy as a tool, binding of 14 lanthanides to a lanthanide-dependent DNAzyme is studied, where the binding affinity is symmetric across the series and the tightest binding occurs with Nd3+ and Ho3+. This trend does not correlate with DNAzyme activity, suggesting that metal binding may not be the rate-limiting step of the DNAzyme catalysis.

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Keywords

DNA, DNAzymes, metal binding, Cleavage

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Citation

URI

http://dx.doi.org/10.1039/C4CC05551A
 http://hdl.handle.net/10012/11369

Collections

Waterloo Research
Chemistry
Waterloo Institute for Nanotechnology