The group trend of lanthanides binding to DNA and DNAzymes with a complex but symmetric pattern
MetadataShow full item record
Using sensitized Tb3+ luminescence spectroscopy as a tool, binding of 14 lanthanides to a lanthanide-dependent DNAzyme is studied, where the binding affinity is symmetric across the series and the tightest binding occurs with Nd3+ and Ho3+. This trend does not correlate with DNAzyme activity, suggesting that metal binding may not be the rate-limiting step of the DNAzyme catalysis.
Cite this work
Wei Ting David Lin, Po-Jung Jimmy Huang, Rachel Pautler, Juewen Liu (2014). The group trend of lanthanides binding to DNA and DNAzymes with a complex but symmetric pattern. UWSpace. http://hdl.handle.net/10012/11369