Two Pb2+-specific DNAzymes with opposite trends in split-site-dependent activity

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Date

2014-05-04

Authors

Huang, Po-Jung Jimmy
Liu, Juewen

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Publisher

Royal Society of Chemistry

Abstract

By splitting the catalytic core of DNAzymes into two halves, two Pb2+-specific DNAzymes retain partial activity, while they show opposite trends of activity as a function of the split site, revealing important nucleotides for catalysis and metal binding.

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Keywords

DNAzymes, catalysis, metal binding, Lead

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