Two Pb2+-specific DNAzymes with opposite trends in split-site-dependent activity
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Date
2014-05-04
Authors
Huang, Po-Jung Jimmy
Liu, Juewen
Advisor
Journal Title
Journal ISSN
Volume Title
Publisher
Royal Society of Chemistry
Abstract
By splitting the catalytic core of DNAzymes into two halves, two Pb2+-specific DNAzymes retain partial activity, while they show opposite trends of activity as a function of the split site, revealing important nucleotides for catalysis and metal binding.
Description
Keywords
DNAzymes, catalysis, metal binding, Lead