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Two Pb2+-specific DNAzymes with opposite trends in split-site-dependent activity

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Liu_Juewen(5).pdf (1023.68 KB)

Date

2014-05-04

Authors

Huang, Po-Jung Jimmy
Liu, Juewen

Journal Title

Journal ISSN

Volume Title

Publisher

Royal Society of Chemistry

Abstract

By splitting the catalytic core of DNAzymes into two halves, two Pb2+-specific DNAzymes retain partial activity, while they show opposite trends of activity as a function of the split site, revealing important nucleotides for catalysis and metal binding.

Description

Keywords

DNAzymes, catalysis, metal binding, Lead

LC Keywords

Citation

URI

http://dx.doi.org/10.1039/C4CC00864B
 http://hdl.handle.net/10012/11358

Collections

Waterloo Research
Chemistry
Waterloo Institute for Nanotechnology