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A platinum shell for ultraslow ligand exchange: unmodified DNA adsorbing more stably on platinum than thiol and dithiol on gold

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Liu_Juewen(15).pdf (973.4 KB)

Date

2015-08-04

Authors

Zhou, Wenhu
Ding, Jinsong
Liu, Juewen

Journal Title

Journal ISSN

Volume Title

Publisher

Royal Society of Chemistry

Abstract

Due to the ultraslow ligand exchange rate on Pt, non-thiolated DNA is adsorbed on platinum nanoparticles (PtNPs) more stably than thiolated and even dithiolated DNA on AuNPs. Adsorption kinetics, capacity and stability are systematically compared as a function of DNA sequence. The Pt conjugates can tolerate extreme pH, salt, and thiol molecules. Taking advantage of the optical properties of AuNPs and the extreme stability of DNA on PtNPs, DNA-functionalized Au@Pt NPs are prepared using a cost-effective and more stable bioconjugation method. The DNA-directed assembly of non-thiolated DNA conjugates is also demonstrated.

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Keywords

DNA, Ligand Exchange, gold, platinum, adsorption

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Citation

URI

http://dx.doi.org/10.1039/C5CC04340A
 http://hdl.handle.net/10012/11343

Collections

Waterloo Research
Chemistry
Waterloo Institute for Nanotechnology