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A platinum shell for ultraslow ligand exchange: unmodified DNA adsorbing more stably on platinum than thiol and dithiol on gold

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dc.contributor.authorZhou, Wenhu
dc.contributor.authorDing, Jinsong
dc.contributor.authorLiu, Juewen
dc.date.accessioned2017-02-23T20:24:24Z
dc.date.available2017-02-23T20:24:24Z
dc.date.issued2015-08-04
dc.description.abstractDue to the ultraslow ligand exchange rate on Pt, non-thiolated DNA is adsorbed on platinum nanoparticles (PtNPs) more stably than thiolated and even dithiolated DNA on AuNPs. Adsorption kinetics, capacity and stability are systematically compared as a function of DNA sequence. The Pt conjugates can tolerate extreme pH, salt, and thiol molecules. Taking advantage of the optical properties of AuNPs and the extreme stability of DNA on PtNPs, DNA-functionalized Au@Pt NPs are prepared using a cost-effective and more stable bioconjugation method. The DNA-directed assembly of non-thiolated DNA conjugates is also demonstrated.en
dc.description.sponsorshipUniversity of Waterloo || Natural Sciences and Engineering Research Council || Foundation for Shenghua Scholar of Central South University || National Natural Science Foundation of China || Grant No. 21301195 China Scholarship Council || CSC, Grant No. 201406370116en
dc.identifier.urihttp://dx.doi.org/10.1039/C5CC04340A
dc.identifier.urihttp://hdl.handle.net/10012/11343
dc.language.isoenen
dc.publisherRoyal Society of Chemistryen
dc.subjectDNAen
dc.subjectLigand Exchangeen
dc.subjectgolden
dc.subjectplatinumen
dc.subjectadsorptionen
dc.titleA platinum shell for ultraslow ligand exchange: unmodified DNA adsorbing more stably on platinum than thiol and dithiol on golden
dc.typeArticleen
dcterms.bibliographicCitationZhou, W., Ding, J., & Liu, J. (2015). A platinum shell for ultraslow ligand exchange: unmodified DNA adsorbing more stably on platinum than thiol and dithiol on gold. Chem. Commun., 51(60), 12084–12087. https://doi.org/10.1039/C5CC04340Aen
uws.contributor.affiliation1Faculty of Scienceen
uws.contributor.affiliation2Chemistryen
uws.contributor.affiliation2Waterloo Institute for Nanotechnology (WIN)en
uws.peerReviewStatusRevieweden
uws.scholarLevelFacultyen
uws.typeOfResourceTexten

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