Browsing University of Waterloo by Subject "SERCA"
Now showing items 1-10 of 10
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Does Sarcolipin Ablation Alter Deflazacort Treatment Effects in mdx Mice?
(University of Waterloo, 2017-09-27)Duchenne Muscular Dystrophy (DMD) and the murine model mdx are degenerative diseases that are characterized by the absence of the protein dystrophin causing membrane instability, calcium (Ca2+) influx, and progressive ... -
Effects of 4-hydroxy-2-nonenal on SERCA pump structure and function in skeletal and cardiac muscle
(University of Waterloo, 2015-11-30)The sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) pumps are approximately 100 kDa transmembranous proteins that catalyze the ATP-dependent transport of cytosolic Ca2+ [Ca2+]i into the sarcoplasmic reticulum (SR), thereby ... -
The Effects of a Calcineurin Inhibitor on Muscle Fibre Type and the Pathology of Centronuclear Myopathy in PlnOE Mice
(University of Waterloo, 2017-01-27)The sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) pump is responsible for pumping calcium from the cytosol back into the lumen of the sarcoplasmic reticulum post contraction. SERCA activity can be reduced by an inhibitory ... -
Effects of Heat Stress on HSP70, Sarcolipin, and Phospholamban Content and SERCA Function in Female and Male Rat Skeletal Muscle
(University of Waterloo, 2023-09-25)Regulation of cytosolic calcium (Ca2+) levels in muscle is vital to the health and function of muscle due to its involvement in various signaling pathways and cell functions. Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) ... -
Examining the Effect of Parvalbumin Overexpression on the Development of Centronuclear Myopathy in Phospholamban Overexpressing Mice
(University of Waterloo, 2022-05-18)Within the myofibre, the sarco(endo)plasmic reticulum (SR) Ca2+ ATPase (SERCA) has an essential role in regulating intracellular Ca2+ concentrations ([Ca2+]i) by pumping Ca2+ into the SR. There are several known regulators ... -
The Role of Heat Shock Protein 70 in Protecting Muscle Mechanical Function & SERCA Function in Human Skeletal Muscle
(University of Waterloo, 2009-04-23)Two studies were conducted to determine if Hsp70 is able to protect human skeletal muscle from muscle mechanical damage and alterations in SERCA activity associated with prolonged concentric exercise. In the first study, ... -
The role of phospholamban (PLN) in potential protection of sarc(endo)plasmic reticulum Ca2+-ATPase (SERCA) against oxidative stress
(University of Waterloo, 2015-01-23)Sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) sequesters Ca2+ from the cytosol to: i) aid in muscular relaxation and ii) refill SR Ca2+ stores for release upon subsequent stimulus for contraction. SERCA function is ... -
The Role of Phospholamban and Sarcolipin in Skeletal Muscle Disease
(University of Waterloo, 2016-01-19)Sarcolipin (SLN) and phospholamban (PLN) are two small proteins that physically interact with and inhibit the sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) pump. Results from our laboratory and others have shown that, ... -
The Role of Sarcolipin in Calcium Handling and Obesity
(University of Waterloo, 2010-05-19)Sarcolipin (SLN), a small molecular weight, hydrophobic protein found in skeletal muscle, is a known regulator of sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) pumps. Earlier in vitro reconstitution experiments have ... -
ROLE OF SECOND MESSENGER SIGNALING PATHWAYS IN THE REGULATION OF SARCOPLASMIC RETICULUM CALCIUM-HANDLING PROPERTIES IN THE LEFT VENTRICLE AND SKELETAL MUSCLES OF DIFFERENT FIBRE TYPE COMPOSITION
(University of Waterloo, 2007-02-09)The overall objective of this thesis was to examine mechanisms involved in the acute regulation of sarcoplasmic reticulum (SR) Ca2+-handling properties by second messenger signaling pathways in skeletal and cardiac muscle. ...