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Deployment of functional DNA-based biosensors for environmental water analysis

dc.contributor.authorZhao, Yichen
dc.contributor.authorYavari, Kayvan
dc.contributor.authorWang, Yihao
dc.contributor.authorPi, Kunfu
dc.contributor.authorVan Cappellen, Philippe
dc.contributor.authorLiu, Juewen
dc.date.accessioned2025-09-22T15:07:48Z
dc.date.available2025-09-22T15:07:48Z
dc.date.issued2022-04-14
dc.descriptionThe final publication is available at Elsevier via https://doi.org/10.1016/j.trac.2022.116639. © 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.description.abstractVarious functional DNA molecules have been used for the detection of environmental contaminants in water, but their practical applications have been limited. To address this gap, this review highlights the efforts to develop field-deployable water quality biosensors. The biosensor devices include microfluidic, lateral flow and paper-based devices, and other novel ideas such as the conversion of glucometers for the detection of environmental analytes. In addition, we also review DNA-functionalized hydrogels and their use in diffusive gradients in thin films (DGT) devices. We classify the sensors into one-step and two-step assays and discuss their practical implications. While the review is focused on works reported in the last five years, some classic early works are cited as well. Overall, most of the existing work only tested spiked water samples. Future work needs to shift to real environmental samples and the comparison of DNA-based sensors to standard analytical methods.
dc.identifier.urihttps://doi.org/10.1016/j.trac.2022.116639
dc.identifier.uri10.1016/j.trac.2022.116639
dc.identifier.urihttps://hdl.handle.net/10012/22505
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofseriesTrends in Analytical Chemistry; 153; 116639
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectaptamers
dc.subjectDNAzymes
dc.subjectgold nanoparticles
dc.subjectbiosensors
dc.subjectfluorescence
dc.subjectlateral flow
dc.subjectmicrofluidics
dc.titleDeployment of functional DNA-based biosensors for environmental water analysis
dc.typeArticle
dcterms.bibliographicCitationZhao, Y., Yavari, K., Wang, Y., Pi, K., Van Cappellen, P., & Liu, J. (2022). Deployment of functional DNA-based biosensors for Environmental Water Analysis. TrAC Trends in Analytical Chemistry, 153, 116639. https://doi.org/10.1016/j.trac.2022.116639
uws.contributor.affiliation1Faculty of Science
uws.contributor.affiliation2Chemistry
uws.peerReviewStatusReviewed
uws.scholarLevelFaculty
uws.typeOfResourceTexten

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