dc.contributor.author	Mrachacz-Kersting, Natalie
dc.contributor.author	Stevenson, Andrew James Thomas
dc.contributor.author	Jørgensen, Helle R. M.
dc.contributor.author	Severinsen, Kåre Eg
dc.contributor.author	Aliakbaryhosseinabadi, Susan
dc.contributor.author	Jiang, Ning
dc.contributor.author	Farina, Dario
dc.date.accessioned	2018-11-16T15:20:25Z
dc.date.available	2018-11-16T15:20:25Z
dc.date.issued	2018-11-08
dc.description	This is the peer reviewed version of the following article: “Brain-State Dependent Stimulation boosts functional recovery following stroke”, which has been published in final form at http://dx.doi.org/10.1002/ana.25375. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived.	en
dc.description.abstract	Objective Adjuvant protocols devised to enhance motor recovery in subacute stroke patients have failed to show benefits with respect to classic therapeutic interventions. Here we evaluate the efficacy of a novel brain-state dependent intervention based on known mechanisms of memory and learning, that is integrated as part of the weekly rehabilitation program in subacute stroke patients. Methods Twenty-four hospitalized subacute stroke patients were randomly assigned to two intervention groups; 1. The associative group received thirty pairings of a peripheral electrical nerve stimulus (ES) such that the generated afferent volley arrived precisely during the most active phase of the motor cortex as patients attempted to perform a movement; 2. In the control group the ES intensity was too low to generate a stimulation of the nerve. Functional (including the lower extremity Fugl-Meyer assessment (LE-FM; primary outcome measure)) and neurophysiological (changes in motor evoked potentials (MEPs)) assessments were performed prior to and following the intervention period. Results The associative group significantly improved functional recovery with respect to the control group (median (interquartile range) LE-FM improvement: 6.5 (3.5-8.25) and 3 (0.75-3), respectively; p=0.029). Significant increases in MEP amplitude were seen following all sessions in the associative group only (p’s≤0.006). Interpretation This is the first evidence of a clinical effect of a neuromodulatory intervention in the subacute phase of stroke. This was evident with relatively few repetitions in comparison to available techniques, making it a clinically-viable approach. The results indicate the potential of the proposed neuromodulation system in daily clinical routine for stroke rehabilitation. This article is protected by copyright. All rights reserved.	en
dc.description.sponsorship	Kong Christian den Tiendes Fond (39/2016)	en
dc.identifier.uri	https://doi.org/10.1002/ana.25375
dc.identifier.uri	http://hdl.handle.net/10012/14160
dc.language.iso	en	en
dc.publisher	Wiley	en
dc.subject	Stroke	en
dc.subject	Cortical	en
dc.subject	Plasticity	en
dc.title	Brain-State Dependent Stimulation boosts functional recovery following stroke	en
dc.type	Article	en
dcterms.bibliographicCitation	Mrachacz‐Kersting, N., Stevenson, A. J. T., Jørgensen, H. R. M., Severinsen, K. E., Aliakbaryhosseinabadi, S., Jiang, N., & Farina, D. (n.d.). Brain-State Dependent Stimulation boosts functional recovery following stroke. Annals of Neurology, (accepted for publication). https://doi.org/10.1002/ana.25375	en
uws.contributor.affiliation1	Faculty of Engineering	en
uws.contributor.affiliation2	Systems Design Engineering	en
uws.peerReviewStatus	Reviewed	en
uws.scholarLevel	Faculty	en
uws.typeOfResource	Text	en

Brain-State Dependent Stimulation boosts functional recovery following stroke

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