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Sex differences in solute and water handling in the human kidney: Modeling and functional implications

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dc.contributor.authorHu, Rui
dc.contributor.authorMcDonough, Alicia A.
dc.contributor.authorLayton, Anita T.
dc.date.accessioned2022-01-28T20:59:53Z
dc.date.available2022-01-28T20:59:53Z
dc.date.issued2021-06
dc.description.abstractThe kidneys maintain homeostasis by controlling the amount of water and electrolytes in the blood. That function is accomplished by the nephrons, which transform glomerular filtrate into urine by a transport process mediated by membrane transporters. We postulate that the distribution of renal transporters along the nephron is markedly different between men and women, as recently shown in rodents. We hypothesize that the larger abundance of a renal Na+ transport in the proximal tubules in females may also better prepare them for the fluid retention adaptations required during pregnancy and lactation. Also, kidneys play a key role in blood pressure regulation, and a popular class of anti-hypertensive medications and angiotensin converting enzymes (ACE) inhibitors have been reported to be less effective in women. Model simulations suggest that the blunted natriuretic and diuretic effects of ACE inhibition in women can be attributed, in part, to their higher distal baseline transport capacity.en
dc.description.sponsorshipNatural Sciences and Engineering Research Council of Canada || National Institutes of Healthen
dc.identifier.urihttps://doi.org/10.1016/j.isci.2021.102667
dc.identifier.urihttp://hdl.handle.net/10012/18011
dc.language.isoenen
dc.publisherElsevieren
dc.relation.ispartofseriesiScience;
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjecthuman physiologyen
dc.subjectbioinformaticsen
dc.subjectmathematical biosciencesen
dc.titleSex differences in solute and water handling in the human kidney: Modeling and functional implicationsen
dc.typeArticleen
dcterms.bibliographicCitationHu, R., McDonough, A. A., & Layton, A. T. (2021). Sex differences in solute and water handling in the human kidney: Modeling and functional implications. IScience, 24(6), 102667. https://doi.org/10.1016/j.isci.2021.102667en
uws.contributor.affiliation1Faculty of Mathematicsen
uws.contributor.affiliation1Faculty of Scienceen
uws.contributor.affiliation2Applied Mathematicsen
uws.contributor.affiliation2Biologyen
uws.contributor.affiliation2David R. Cheriton School of Computer Scienceen
uws.contributor.affiliation2School of Pharmacyen
uws.peerReviewStatusRevieweden
uws.scholarLevelFacultyen
uws.typeOfResourceTexten

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