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Emergence and Spread of the SARS-CoV-2 Omicron Variant in Alberta Communities Revealed by Wastewater Monitoring

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dc.contributor.authorHubert, Casey R. J.
dc.contributor.authorAcosta, Nicole
dc.contributor.authorWaddell, Barbara J.
dc.contributor.authorHasing, Maria E.
dc.contributor.authorQiu, Yuanyuan
dc.contributor.authorFuzzen, Meghan
dc.contributor.authorHarper, Nathanael B. J.
dc.contributor.authorBautista, María A.
dc.contributor.authorGao, Tiejun
dc.contributor.authorPapparis, Chloe
dc.contributor.authorDoorn, Jean V.
dc.contributor.authorDu, Kristine
dc.contributor.authorXiang, Kevin
dc.contributor.authorChan, Leslie
dc.contributor.authorVivas, Laura
dc.contributor.authorPradhan, Puja
dc.contributor.authorMcCalder, Janine
dc.contributor.authorLow, Kashtin
dc.contributor.authorEngland, Whitney E.
dc.contributor.authorKuzma, Darina
dc.contributor.authorConly, John
dc.contributor.authorRyan, M. Cathryn
dc.contributor.authorAchari, Gopal
dc.contributor.authorHu, Jia
dc.contributor.authorCabaj, Jason L.
dc.contributor.authorSikora, Chris
dc.contributor.authorSvenson, Larry
dc.contributor.authorZelyas, Nathan
dc.contributor.authorServos, Mark. R.
dc.contributor.authorMeddings, Jon
dc.contributor.authorHrudey, Steve E.
dc.contributor.authorFrankowski, Kevin
dc.contributor.authorParkins, Michael D.
dc.contributor.authorPang, Xiaoli
dc.contributor.authorLee, Bonita E.
dc.date.accessioned2022-06-15T16:59:01Z
dc.date.available2022-06-15T16:59:01Z
dc.date.issued2022-10-03
dc.description.abstractWastewater monitoring of SARS-CoV-2 allows for early detection and monitoring of COVID-19 burden in communities and can track specific variants of concern. Targeted assays enabled relative proportions of SARS-CoV-2 Omicron and Delta variants to be determined across 30 municipalities covering >75% of the province of Alberta (pop. 4.5M) in Canada, from November 2021 to January 2022. Larger cities like Calgary and Edmonton exhibited a more rapid emergence of Omicron relative to smaller and more remote municipalities. Notable exceptions were Banff, a small international resort town, and Fort McMurray, a more remote northern city with a large fly-in worker population. The integrated wastewater signal revealed that the Omicron variant represented close to 100% of SARS-CoV-2 burden prior to the observed increase in newly diagnosed clinical cases throughout Alberta, which peaked two weeks later. These findings demonstrate that wastewater monitoring offers early and reliable population-level results for establishing the extent and spread of emerging pathogens including SARS-CoV-2 variants.en
dc.description.sponsorshipAlberta Healthen
dc.identifier.urihttps://doi.org/10.1101/2022.03.07.22272055
dc.identifier.urihttp://hdl.handle.net/10012/18384
dc.language.isoenen
dc.publishermedRxiven
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectSARS-CoV-2 Omicron varianten
dc.subjectwastewater monitoringen
dc.titleEmergence and Spread of the SARS-CoV-2 Omicron Variant in Alberta Communities Revealed by Wastewater Monitoringen
dc.typePreprinten
dcterms.bibliographicCitationHubert, C. R. J., Acosta, N., Waddell, B. J., Hasing, M. E., Qiu, Y., Fuzzen, M., Harper, N. B. J., Bautista, M. A., Gao, T., Papparis, C., Doorn, J. V., Du, K., Xiang, K., Chan, L., Vivas, L., Pradhan, P., McCalder, J., Low, K., England, W. E., … Lee, B. E. (2022). Emergence and Spread of the SARS-CoV-2 Omicron Variant in Alberta Communities Revealed by Wastewater Monitoring (p. 2022.03.07.22272055). medRxiv. https://doi.org/10.1101/2022.03.07.22272055en
uws.contributor.affiliation1Faculty of Scienceen
uws.contributor.affiliation2Biologyen
uws.contributor.affiliation2Chemistryen
uws.peerReviewStatusUnrevieweden
uws.scholarLevelFacultyen
uws.typeOfResourceTexten

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