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Spiky gold shells on magnetic particles for DNA biosensors

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dc.contributor.authorBedford, Erin E.
dc.contributor.authorBoujday, Souhir
dc.contributor.authorPradier, Claire-Marie
dc.contributor.authorGu, Frank X.
dc.date.accessioned2018-03-21T13:41:51Z
dc.date.available2018-03-21T13:41:51Z
dc.date.issued2018-05-15
dc.descriptionThe final publication is available at Elsevier via http://dx.doi.org/10.1016/j.talanta.2018.01.094 © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.description.abstractCombined separation and detection of biomolecules has the potential to speed up and improve the sensitivity of disease detection, environmental testing, and biomolecular analysis. In this work, we synthesized magnetic particles coated with spiky nanostructured gold shells and used them to magnetically separate out and detect oligonucleotides using SERS. The distance dependence of the SERS signal was then harnessed to detect DNA hybridization using a Raman label bound to a hairpin probe. The distance of the Raman label from the surface increased upon complementary DNA hybridization, leading to a decrease in signal intensity. This work demonstrates the use of the particles for combined separation and detection of oligonucleotides without the use of an extrinsic tag or secondary hybridization step.en
dc.description.sponsorshipNatural Sciences and Engineering Research Council of Canada (NSERC)en
dc.description.sponsorshipErasmus-sponsored International Doctoral School in Functional Materials (IDS-FunMat)en
dc.identifier.urihttp://dx.doi.org/10.1016/j.talanta.2018.01.094
dc.identifier.urihttp://hdl.handle.net/10012/13044
dc.language.isoenen
dc.publisherElsevieren
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectDNA biosensoren
dc.subjectMagnetic particlesen
dc.subjectNanostructured golden
dc.subjectPlasmonicen
dc.subjectSERSen
dc.titleSpiky gold shells on magnetic particles for DNA biosensorsen
dc.typeArticleen
dcterms.bibliographicCitationBedford, E. E., Boujday, S., Pradier, C.-M., & Gu, F. X. (2018). Spiky gold shells on magnetic particles for DNA biosensors. Talanta, 182, 259–266. https://doi.org/10.1016/j.talanta.2018.01.094en
uws.contributor.affiliation1Faculty of Engineeringen
uws.contributor.affiliation2Chemical Engineeringen
uws.peerReviewStatusRevieweden
uws.scholarLevelFacultyen
uws.typeOfResourceTexten
uws.typeOfResourceTexten

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