UWSpace is currently experiencing technical difficulties resulting from its recent migration to a new version of its software. These technical issues are not affecting the submission and browse features of the site. UWaterloo community members may continue submitting items to UWSpace. We apologize for the inconvenience, and are actively working to resolve these technical issues.
 

Harnessing catalytic pumps for directional delivery of microparticles in microchambers

Simple item page
dc.contributor.authorDas, Sambeeta
dc.contributor.authorShklyaev, Oleg E.
dc.contributor.authorAltemose, Alicia
dc.contributor.authorShum, Henry
dc.contributor.authorOrtiz-Rivera, Isamar
dc.contributor.authorValdez, Lyanne
dc.contributor.authorMallouk, Thomas E.
dc.contributor.authorBalazs, Anna C.
dc.contributor.authorSen, Ayusman
dc.date.accessioned2019-03-07T16:11:26Z
dc.date.available2019-03-07T16:11:26Z
dc.date.issued2017-02-17
dc.description.abstractThe directed transport of microparticles in microfluidic devices is vital for efficient bioassays and fabrication of complex microstructures. There remains, however, a need for methods to propel and steer microscopic cargo that do not require modifying these particles. Using theory and experiments, we show that catalytic surface reactions can be used to deliver microparticle cargo to specified regions in microchambers. Here reagents diffuse from a gel reservoir and react with the catalyst-coated surface. Fluid density gradients due to the spatially varying reagent concentration induce a convective flow, which carries the suspended particles until the reagents are consumed. Consequently, the cargo is deposited around a specific position on the surface. The velocity and final peak location of the cargo can be tuned independently. By increasing the local particle concentration, highly sensitive assays can be performed efficiently and rapidly. Moreover, the process can be repeated by introducing fresh reagent into the microchamber.en
dc.identifier.urihttps://dx.doi.org/10.1038/ncomms14384
dc.identifier.urihttp://hdl.handle.net/10012/14485
dc.publisherSpringer Natureen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectchemical-potential gradientsen
dc.subjectmicrofluidic transporten
dc.subjectmicropumpsen
dc.subjectnanoscaleen
dc.subjectdrivenen
dc.subjectseparationen
dc.subjectcaptureen
dc.subjectflowen
dc.titleHarnessing catalytic pumps for directional delivery of microparticles in microchambersen
dc.typeArticleen
dcterms.bibliographicCitationDas, S., Shklyaev, O. E., Altemose, A., Shum, H., Ortiz-Rivera, I., Valdez, L., … Sen, A. (2017). Harnessing catalytic pumps for directional delivery of microparticles in microchambers. Nature Communications, 8, 14384. doi:10.1038/ncomms14384en
uws.contributor.affiliation1Faculty of Mathematicsen
uws.contributor.affiliation2Applied Mathematicsen
uws.peerReviewStatusRevieweden
uws.scholarLevelFacultyen
uws.typeOfResourceTexten
uws.typeOfResourcetexten

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ncomms14384.pdf
Size:
1.8 MB
Format:
Adobe Portable Document Format
Download

Collections

Waterloo Research
Applied Mathematics