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Tandem Phosphorothioate Modifications for DNA Adsorption Strength and Polarity Control on Gold Nanoparticles

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dc.contributor.authorZhou, Wenhu
dc.contributor.authorWang, Feng
dc.contributor.authorDing, Jinsong
dc.contributor.authorLiu, Juewen
dc.date.accessioned2017-02-27T20:42:01Z
dc.date.available2017-02-27T20:42:01Z
dc.date.issued2014-09-10
dc.descriptionThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Applied Materials & Interfaces, copyright © American Chemical Society after peer review and technical editing by publisher. To access the final edited and published work see Zhou, W., Wang, F., Ding, J., & Liu, J. (2014). Tandem Phosphorothioate Modifications for DNA Adsorption Strength and Polarity Control on Gold Nanoparticles. ACS Applied Materials & Interfaces, 6(17), 14795–14800. https://doi.org/10.1021/am504791ben
dc.description.abstractUnmodified DNA was recently used to functionalize gold nanoparticles via DNA base adsorption. Compared to thiolated DNA, however, the application of unmodified DNA is limited by the lack of sequence generality, adsorption polarity control and poor adsorption stability. We report that these problems can be solved using phosphorothioate (PS) DNA. PS DNA binds to gold mainly via the sulfur atom and is thus less sequence dependent. The adsorption affinity is ranked to be thiol > PS > adenine > thymine. Tandem PS improves adsorption strength, allows tunable DNA density, and the resulting conjugates are functional at a low cost.en
dc.description.sponsorshipUniversity of Waterloo || Natural Sciences and Engineering Research Council || Foundation for Shenghua Scholar of Central South University || National Natural Science Foundation of China || Grant No. 21301195en
dc.identifier.urihttp://dx.doi.org/10.1021/am504791b
dc.identifier.urihttp://hdl.handle.net/10012/11370
dc.language.isoenen
dc.publisherAmerican Chemical Societyen
dc.subjectadsorptionen
dc.subjectDNAen
dc.subjectgold nanoparticlesen
dc.subjectnanotechnologyen
dc.subjectphosphorothioateen
dc.subjectself-assemblyen
dc.titleTandem Phosphorothioate Modifications for DNA Adsorption Strength and Polarity Control on Gold Nanoparticlesen
dc.typeArticleen
dcterms.bibliographicCitationZhou, W., Wang, F., Ding, J., & Liu, J. (2014). Tandem Phosphorothioate Modifications for DNA Adsorption Strength and Polarity Control on Gold Nanoparticles. ACS Applied Materials & Interfaces, 6(17), 14795–14800. https://doi.org/10.1021/am504791ben
uws.contributor.affiliation1Faculty of Scienceen
uws.contributor.affiliation2Chemistryen
uws.contributor.affiliation2Waterloo Institute for Nanotechnology (WIN)en
uws.peerReviewStatusRevieweden
uws.scholarLevelFacultyen
uws.typeOfResourceTexten

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