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Self-assembled manganese phthalocyanine nanoparticles with enhanced peroxidase-like activity for anti-tumor therapy Research Article Published: 29 September 2021

dc.contributor.authorWang, Jinghan
dc.contributor.authorGao, Shanqing
dc.contributor.authorWang, Xiao
dc.contributor.authorZhang, Haozhen
dc.contributor.authorRen, Xitong
dc.contributor.authorLiu, Juewen
dc.contributor.authorBai, Feng
dc.date.accessioned2025-09-23T15:21:49Z
dc.date.available2025-09-23T15:21:49Z
dc.date.issued2021-09-29
dc.descriptionThis is a post-peer-review, pre-copyedit version of an article published in Nano Research. The final authenticated version is available online at: https://doi.org/10.1007/s12274-021-3854-5
dc.description.abstractThe use of functional nanoparticles as peroxidase-like (POD-like) catalyst has recently become a focus of research in cancer therapy. Phthalocyanine is a macrocyclic conjugated metal ligand, which is expected to achieve a high POD-like catalytic activity, generating free radicals and inhibiting the proliferation of cancer cells. In this paper, we synthesized phthalocyanine nanocrystals with different structures through noncovalent self-assembly confined within micro-emulsion droplets, and manganese phthalocyanine (MnPc) possessing a metal-N-C active center was used as the building block. These nano-assemblies exhibit shape-dependent POD-like catalytic activities, because the emulsifier and MnPc co-mixed assembly reduced the close packing between MnPc molecules and exposed more active sites. The assembly had a water-dispersed nanostructure, which is conducive to accumulation at tumor sites through the enhanced permeability and retention effect (EPR). Because of a highly efficient microenvironmental response, the assembly showed higher catalytic activity only emerged under the acidic tumor-like microenvironment, but caused less damage to normal tissues in biomedical applications. In vivo and in vitro catalytic therapy tests showed excellent anti-tumor effects. This work explored a new way for the application of metal-organic macromolecules such as MnPc as nanozymes for catalytic tumor therapy.
dc.identifier.urihttps://doi.org/10.1007/s12274-021-3854-5
dc.identifier.uri10.1007/s12274-021-3854-5
dc.identifier.urihttps://hdl.handle.net/10012/22539
dc.language.isoen
dc.relation.ispartofseriesNano Research; 15(3)
dc.rightsAttribution-NonCommercial-ShareAlike 2.5 Canadaen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/2.5/ca/
dc.titleSelf-assembled manganese phthalocyanine nanoparticles with enhanced peroxidase-like activity for anti-tumor therapy Research Article Published: 29 September 2021
dc.typeArticle
dcterms.bibliographicCitationWang, J., Gao, S., Wang, X., Zhang, H., Ren, X., Liu, J., & Bai, F. (2021a). Self-assembled manganese phthalocyanine nanoparticles with enhanced peroxidase-like activity for anti-tumor therapy. Nano Research, 15(3), 2347–2354. https://doi.org/10.1007/s12274-021-3854-5
uws.contributor.affiliation1Faculty of Science
uws.contributor.affiliation2Chemistry
uws.peerReviewStatusReviewed
uws.scholarLevelFaculty
uws.typeOfResourceTexten

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