Self-assembled manganese phthalocyanine nanoparticles with enhanced peroxidase-like activity for anti-tumor therapy Research Article Published: 29 September 2021
dc.contributor.author | Wang, Jinghan | |
dc.contributor.author | Gao, Shanqing | |
dc.contributor.author | Wang, Xiao | |
dc.contributor.author | Zhang, Haozhen | |
dc.contributor.author | Ren, Xitong | |
dc.contributor.author | Liu, Juewen | |
dc.contributor.author | Bai, Feng | |
dc.date.accessioned | 2025-09-23T15:21:49Z | |
dc.date.available | 2025-09-23T15:21:49Z | |
dc.date.issued | 2021-09-29 | |
dc.description | This is a post-peer-review, pre-copyedit version of an article published in Nano Research. The final authenticated version is available online at: https://doi.org/10.1007/s12274-021-3854-5 | |
dc.description.abstract | The use of functional nanoparticles as peroxidase-like (POD-like) catalyst has recently become a focus of research in cancer therapy. Phthalocyanine is a macrocyclic conjugated metal ligand, which is expected to achieve a high POD-like catalytic activity, generating free radicals and inhibiting the proliferation of cancer cells. In this paper, we synthesized phthalocyanine nanocrystals with different structures through noncovalent self-assembly confined within micro-emulsion droplets, and manganese phthalocyanine (MnPc) possessing a metal-N-C active center was used as the building block. These nano-assemblies exhibit shape-dependent POD-like catalytic activities, because the emulsifier and MnPc co-mixed assembly reduced the close packing between MnPc molecules and exposed more active sites. The assembly had a water-dispersed nanostructure, which is conducive to accumulation at tumor sites through the enhanced permeability and retention effect (EPR). Because of a highly efficient microenvironmental response, the assembly showed higher catalytic activity only emerged under the acidic tumor-like microenvironment, but caused less damage to normal tissues in biomedical applications. In vivo and in vitro catalytic therapy tests showed excellent anti-tumor effects. This work explored a new way for the application of metal-organic macromolecules such as MnPc as nanozymes for catalytic tumor therapy. | |
dc.identifier.uri | https://doi.org/10.1007/s12274-021-3854-5 | |
dc.identifier.uri | 10.1007/s12274-021-3854-5 | |
dc.identifier.uri | https://hdl.handle.net/10012/22539 | |
dc.language.iso | en | |
dc.relation.ispartofseries | Nano Research; 15(3) | |
dc.rights | Attribution-NonCommercial-ShareAlike 2.5 Canada | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/2.5/ca/ | |
dc.title | Self-assembled manganese phthalocyanine nanoparticles with enhanced peroxidase-like activity for anti-tumor therapy Research Article Published: 29 September 2021 | |
dc.type | Article | |
dcterms.bibliographicCitation | Wang, J., Gao, S., Wang, X., Zhang, H., Ren, X., Liu, J., & Bai, F. (2021a). Self-assembled manganese phthalocyanine nanoparticles with enhanced peroxidase-like activity for anti-tumor therapy. Nano Research, 15(3), 2347–2354. https://doi.org/10.1007/s12274-021-3854-5 | |
uws.contributor.affiliation1 | Faculty of Science | |
uws.contributor.affiliation2 | Chemistry | |
uws.peerReviewStatus | Reviewed | |
uws.scholarLevel | Faculty | |
uws.typeOfResource | Text | en |
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