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Multiscale models of kidney function and diseases

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dc.contributor.authorLayton, Anita T.
dc.date.accessioned2019-12-11T19:20:54Z
dc.date.available2019-12-11T19:20:54Z
dc.date.issued2019-09
dc.descriptionThe final publication is available at Elsevier via https://doi.org/10.1016/j.cobme.2019.09.006. © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.description.abstractThe kidney is a complex system whose function is the result of synergistic operations among a number of biological processes. The spatial and functional scales of those processes span a wide range. To interrogate kidney function, one may apply multiscale models. Such models typically couple subcellular processes mediated by membrane channels and transporters, cellular processes, and supracellular processes such as nephron transport and renal autoregulation. We describe the approaches by which biological processes across scales can be coupled, and we highlight the successes of these multiscale models in revealing insights into kidney function under physiological, pathophysiological, or therapeutic conditions.en
dc.description.sponsorshipThis research was supported by the Canada 150 Research Chair program and by the National Institutes of Health via National Institute of Diabetes and Digestive and Kidney Diseases, grant R01DK106102.en
dc.identifier.urihttps://doi.org/10.1016/j.cobme.2019.09.006
dc.identifier.urihttp://hdl.handle.net/10012/15305
dc.language.isoenen
dc.publisherElsevieren
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectrenal transportersen
dc.subjectmembrane channelsen
dc.subjectepithelial cellen
dc.subjectdiabetesen
dc.subjectSGLT2 inhibitorsen
dc.titleMultiscale models of kidney function and diseasesen
dc.typeArticleen
dcterms.bibliographicCitationA.T. Layton, Multiscale Models of Kidney Function and Diseases, Current Opinion in Biomedical Engineering, https://doi.org/10.1016/j.cobme.2019.09.006.en
uws.contributor.affiliation1Faculty of Mathematicsen
uws.contributor.affiliation1Faculty of Scienceen
uws.contributor.affiliation2Applied Mathematicsen
uws.contributor.affiliation2Biologyen
uws.contributor.affiliation2School of Pharmacyen
uws.peerReviewStatusRevieweden
uws.scholarLevelFacultyen
uws.typeOfResourceTexten

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