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Fatigue related impairments in oculomotor control are prevented by caffeine

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dc.contributor.authorConnell, Charlotte J. W.
dc.contributor.authorThompson, Benjamin
dc.contributor.authorKuhn, Gustav
dc.contributor.authorClaffey, Michael P.
dc.contributor.authorDuncan, Shelley
dc.contributor.authorGant, Nicholas
dc.date.accessioned2017-03-16T18:35:42Z
dc.date.available2017-03-16T18:35:42Z
dc.date.issued2016-05-25
dc.descriptionConnell, C. J. W. et al. Fatigue related impairments in oculomotor control are prevented by caffeine. Sci. Rep. 6, 26614; doi: 10.1038/srep26614 (2016)en
dc.description.abstractStrenuous exercise can result in an inability of the central nervous system to drive skeletal muscle effectively, a phenomenon known as central fatigue. The impact of central fatigue on the oculomotor system is currently unexplored. Fatigue that originates in the central nervous system may be related to perturbations in the synthesis and metabolism of several neurotransmitters. In this study we examine central fatigue in the oculomotor system after prolonged exercise. The involvement of central neurotransmission was explored by administering caffeine during exercise. Within a double-blind, randomized, repeated measures, crossover design, 11 cyclists consumed a placebo or caffeine solution during 180 min of stationary cycling. Saccadic eye movements were measured using infra-red oculography. Exercise decreased saccade velocity by 8% (placebo trial). This effect was reversed by caffeine, whereby velocity was increased by 11% after exercise. A non-oculomotor perceptual task (global motion processing) was unaffected by exercise. The human oculomotor system is impaired by strenuous exercise of the locomotor system. Caffeine exerts a protective effect on oculomotor control, which could be related to up-regulated central neurotransmission. In addition, cortical processes supporting global motion perception appear to be robust to fatigue.en
dc.description.sponsorshipThis study was funded by the University of Auckland.en
dc.identifier.urihttp://dx.doi.org/10.1038/srep26614
dc.identifier.urihttp://hdl.handle.net/10012/11512
dc.language.isoenen
dc.publisherNatureen
dc.rightsAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectNeurophysiologyen
dc.subjectSaccadesen
dc.titleFatigue related impairments in oculomotor control are prevented by caffeineen
dc.typeArticleen
dcterms.bibliographicCitationConnell, C. J. W., Thompson, B., Kuhn, G., Claffey, M. P., Duncan, S., & Gant, N. (2016). Fatigue related impairments in oculomotor control are prevented by caffeine. Scientific Reports, 6(1). https://doi.org/10.1038/srep26614en
uws.contributor.affiliation1Faculty of Scienceen
uws.contributor.affiliation2School of Optometry and Vision Scienceen
uws.peerReviewStatusRevieweden
uws.scholarLevelFacultyen
uws.typeOfResourceTexten

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