Composite likelihood for joint analysis of multiple multistate processes via copulas
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Date
2014-10
Authors
Cook, Richard J.
Diao, Liqun
Advisor
Journal Title
Journal ISSN
Volume Title
Publisher
Oxford Journals
Abstract
A copula-based model is described which enables joint analysis of multiple progressive multistate
processes. Unlike intensity-based or frailty-based approaches to joint modeling, the copula
formulation proposed herein ensures that a wide range of marginal multistate processes can be
specified and the joint model will retain these marginal features. The copula formulation also
facilitates a variety of approaches to estimation and inference including composite likelihood and
two-stage estimation procedures. We consider processes with Markov margins in detail, which
are often suitable when chronic diseases are progressive in nature. We give special attention to
the setting in which individuals are examined intermittently and transition times are consequently
interval-censored. Simulation studies give empirical insight into the different methods of analysis
and an application involving progression in joint damage in psoriatic arthritis provides further
illustration.
Description
This is a pre-copyedited, author-produced PDF of an article accepted for publication in Biostatistics following peer review. The version of record Biostat (2014) 15 (4): 690-705 first published online April 9, 2014 doi:10.1093/biostatistics/kxu011 is available online at: http://dx.doi.org/10.1093/biostatistics/kxu011