Interaction Potency of Single-Walled Carbon Nanotubes with DNAs: A Novel Assay for Assessment of Hazard Risk
| dc.contributor.author | Yao, Chunhe | |
| dc.contributor.author | Carlisi, Cristina | |
| dc.contributor.author | Li, Yuning | |
| dc.contributor.author | Chen, Da | |
| dc.contributor.author | Ding, Jianfu | |
| dc.contributor.author | Feng, Yong-Lai | |
| dc.date.accessioned | 2026-05-21T16:24:01Z | |
| dc.date.available | 2026-05-21T16:24:01Z | |
| dc.date.issued | 2016-12-09 | |
| dc.description | © 2016 Yao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
| dc.description.abstract | Increasing use of single-walled carbon nanotubes (SWCNTs) necessitates a novel method for hazard risk assessment. In this work, we investigated the interaction of several types of commercial SWCNTs with single-stranded (ss) and double-stranded (ds) DNA oligonucleotides (20-mer and 20 bp). Based on the results achieved, we proposed a novel assay that employed the DNA interaction potency to assess the hazard risk of SWCNTs. It was found that SWCNTs in different sizes or different batches of the same product number of SWCNTs showed dramatically different potency of interaction with DNAs. In addition, the same SWCNTs also exerted strikingly different interaction potency with ss- versus ds- DNAs. The interaction rates of SWCNTs with DNAs were investigated, which could be utilized as the indicator of potential hazard for acute exposure. Compared to solid SWCNTs, the SWCNTs dispersed in liquid medium (2% sodium cholate solution) exhibited dramatically different interaction potency with DNAs. This indicates that the exposure medium may greatly influence the subsequent toxicity and hazard risk produced by SWCNTs. Based on the findings of dose-dependences and time-dependences from the interactions between SWCNTs and DNAs, a new chemistry based assay for hazard risk assessment of nanomaterials including SWCNTs has been presented. | |
| dc.description.sponsorship | Natural Sciences and Engineering Research Council of Canada (NSERC) || Health Canada || Chemicals Management Plan (CMP). | |
| dc.identifier.uri | https://doi.org/10.1371/journal.pone.0167796 | |
| dc.identifier.uri | https://hdl.handle.net/10012/23371 | |
| dc.language.iso | en | |
| dc.publisher | Public Library of Science | |
| dc.relation.ispartofseries | PLoS ONE; 11(12); e0167796 | |
| dc.rights | Attribution 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | carbon nanotubes | |
| dc.subject | nanomaterials | |
| dc.subject | oligonucleotides | |
| dc.subject | toxicity | |
| dc.subject | drug interactions | |
| dc.subject | sonication | |
| dc.subject | medical risk factors | |
| dc.subject | DNA damage | |
| dc.title | Interaction Potency of Single-Walled Carbon Nanotubes with DNAs: A Novel Assay for Assessment of Hazard Risk | |
| dc.type | Article | |
| dcterms.bibliographicCitation | Yao C, Carlisi C, Li Y, Chen D, Ding J, Feng Y-L (2016) Interaction Potency of Single-Walled Carbon Nanotubes with DNAs: A Novel Assay for Assessment of Hazard Risk. PLoS ONE 11(12): e0167796. https://doi.org/10.1371/journal.pone.0167796 | |
| uws.contributor.affiliation1 | Faculty of Engineering | |
| uws.contributor.affiliation2 | Chemical Engineering | |
| uws.peerReviewStatus | Reviewed | |
| uws.scholarLevel | Faculty | |
| uws.typeOfResource | Text | en |