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Whole blood long-chain n-3 fatty acids as a measure of fish oil compliance in children with acute lymphoblastic leukemia: a pilot study

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dc.contributor.authorLaumann, R. D.
dc.contributor.authorIversen, T.
dc.contributor.authorFrandsen, T. L.
dc.contributor.authorMølgaard, C.
dc.contributor.authorStark, Ken
dc.contributor.authorSchmiegelow, K.
dc.contributor.authorLauritzen, L.
dc.date.accessioned2022-01-24T17:59:13Z
dc.date.available2022-01-24T17:59:13Z
dc.date.issued2022-01
dc.description.abstractLong-chain n-3 fatty acids (n-3 LCPUFA) may prevent chemotherapy-induced hyperlipidemia in children with acute lymphoblastic leukemia (ALL). However, compliance could be a problem and intake-biomarker correlations may be affected by bodyweight and blood transfusions. We assessed whole blood n-3 LCPUFA three times during the first 83 days of treatment in six 1-17-year-old children with ALL, who received 2.4-4.9 g/d n-3 LCPUFA depending on bodyweight. Mean compliance was 73%, which resulted in a 2.5-fold increase in blood n-3 LCPUFA irrespective of blood transfusions. The correlation between relative blood content of n-3 LCPUFA and intake in g/d across the study period was strong (r=0.76, p=0.001). When n-3 LCPUFA was expressed in absolute concentrations and intake per kg bodyweight the correlation decreased (r=0.39, p=0.164) and was driven by baseline values. Thus, relative content of n-3 LCPUFA in blood reflects fish oil compliance in children with ALL despite blood transfusions and differences in bodyweight.en
dc.identifier.urihttps://doi.org/10.1016/j.plefa.2022.102401
dc.identifier.urihttp://hdl.handle.net/10012/17951
dc.language.isoenen
dc.publisherElsevieren
dc.relation.ispartofseriesProstaglandins, Leukotrienes and Essential Fatty Acids;
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectomega-3 fatty acidsen
dc.subjectdose-response-relationshipen
dc.subjectdietary biomarkersen
dc.subjectcanceren
dc.subjectacute lymphoblastic leukemiaen
dc.subjectchildrenen
dc.titleWhole blood long-chain n-3 fatty acids as a measure of fish oil compliance in children with acute lymphoblastic leukemia: a pilot studyen
dc.typeArticleen
dcterms.bibliographicCitationLaumann, R. D., Iversen, T., Frandsen, T. L., Mølgaard, C., Stark, K. D., Schmiegelow, K., & Lauritzen, L. (2022). nWhole blood long-chain n-3 fatty acids as a measure of fish oil compliance in children with acute lymphoblastic leukemia: A pilot study. Prostaglandins, Leukotrienes and Essential Fatty Acids, 0(0). https://doi.org/10.1016/j.plefa.2022.102401en
uws.contributor.affiliation1Faculty of Applied Health Sciencesen
uws.contributor.affiliation2Kinesiologyen
uws.peerReviewStatusRevieweden
uws.scholarLevelFacultyen
uws.typeOfResourceTexten

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