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Controlling “chemical nose” biosensor characteristics by modulating gold nanoparticle shape and concentration

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dc.contributor.authorVerma, Mohit S.
dc.contributor.authorChen, Paul Z.
dc.contributor.authorJones, Lyndon W.
dc.contributor.authorGu, Frank X.
dc.date.accessioned2017-03-07T19:47:54Z
dc.date.available2017-03-07T19:47:54Z
dc.date.issued2015-09
dc.descriptionVerma, M. S., Chen, P. Z., Jones, L., & Gu, F. X. (2015). Controlling “chemical nose” biosensor characteristics by modulating gold nanoparticle shape and concentration. Sensing and Bio-Sensing Research, 5, 13–18. https://doi.org/10.1016/j.sbsr.2015.04.007en
dc.description.abstractConventional lock-and-key biosensors often only detect a single pathogen because they incorporate biomolecules with high specificity. “Chemical nose” biosensors are overcoming this limitation and identifying multiple pathogens simultaneously by obtaining a unique set of responses for each pathogen of interest, but the number of pathogens that can be distinguished is limited by the number of responses obtained. Herein, we use a gold nanoparticle-based “chemical nose” to show that changing the shapes of nanoparticles can increase the number of responses available for analysis and expand the types of bacteria that can be identified. Using four shapes of nanoparticles (nanospheres, nanostars, nanocubes, and nanorods), we demonstrate that each shape provides a unique set of responses in the presence of different bacteria, which can be exploited for enhanced specificity of the biosensor. Additionally, the concentration of nanoparticles controls the detection limit of the biosensor, where a lower concentration provides better detection limit. Thus, here we lay a foundation for designing “chemical nose” biosensors and controlling their characteristics using gold nanoparticle morphology and concentration.en
dc.identifier.urihttp://hdl.handle.net/10012/11451
dc.identifier.urihttp://dx.doi.org/10.1016/j.sbsr.2015.04.007
dc.language.isoenen
dc.publisherElsevieren
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMorphologyen
dc.subjectColor changeen
dc.subjectStaphylococcus aureusen
dc.subjectPoint-of-careen
dc.subjectNanocubesen
dc.subjectNanorodsen
dc.titleControlling “chemical nose” biosensor characteristics by modulating gold nanoparticle shape and concentrationen
dc.typeArticleen
dcterms.bibliographicCitationVerma, M. S., Chen, P. Z., Jones, L., & Gu, F. X. (2015). Controlling “chemical nose” biosensor characteristics by modulating gold nanoparticle shape and concentration. Sensing and Bio-Sensing Research, 5, 13–18. https://doi.org/10.1016/j.sbsr.2015.04.007en
uws.contributor.affiliation1Faculty of Scienceen
uws.contributor.affiliation2School of Optometry and Vision Scienceen
uws.peerReviewStatusRevieweden
uws.scholarLevelFacultyen
uws.typeOfResourceTexten

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