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Browsing Pharmacy by Subject "hemophilia A"
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Modeling of Body Weight Metrics for Effective and Cost-Efficient Conventional Factor VIII Dosing in Hemophilia A Prophylaxis (MDPI, 2017-12-01)The total body weight-based dosing strategy currently used in the prophylactic treatment of hemophilia A may not be appropriate for all populations. The assumptions that guide weight-based dosing are not valid in overweight ...
Pharmacokinetic modelling of clinically relevant situations in the treatment of hemophilia A and B (University of Waterloo, 2020-04-03)Hemophilia is a congenital bleeding disorder caused by deficiency of clotting factor VIII (FVIII; hemophilia A) or IX (FIX; hemophilia B). Severe hemophilia patients have less than 1% (or 1 IU/dL) of normal factor activity, ...