Browsing Optometry and Vision Science by Author "Subbaraman, Lakshman N."
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Development of an In Vitro Ocular Platform to Test Contact Lenses
Phan, Chau-Minh; Walther, Hendrik; Gao, Huayi; Rossy, Jordan; Subbaraman, Lakshman N.; Jones, Lyndon W. (Journal of Visualized Experiments, 2016-06-04)Currently, in vitro evaluations of contact lenses (CLs) for drug delivery are typically performed in large volume vials,1-6 which fail to mimic physiological tear volumes.7 The traditional model also lacks the natural tear ... -
Impression Cytology of the Lid Wiper Area
Jones, Lyndon W.; Subbaraman, Lakshman N.; Muntz, Alex; van Doorn, Kevin (Journal of Visualized Experiments, 2016-09-08)Few reports on the cellular anatomy of the lid wiper (LW) area of the inner eyelid exist and only one report makes use of cytological methods. The optimization of a method of collecting, staining and imaging cells from the ... -
Insights to Using Contact Lenses for Drug Delivery
Phan, Chau-Minh; Walther, Hendrik; Gao, Huayi; Rossy, Jordan; Subbaraman, Lakshman N.; Jones, Lyndon W. (Omics International, 2013)There has been considerable interest in the potential application of contact lenses for ocular drug delivery. This short communication provides an overview of the challenges faced by delivering drugs using contact lenses, ... -
Release of Ciprofloxacin and Moxifloxacin From Daily Disposable Contact Lenses From an In Vitro Eye Model
Bajgrowicz-Cieslak, Magdalena; Phan, Chau-Minh; Subbaraman, Lakshman N.; Jones, Lyndon W. (Association for Research in Vision and Ophthalmology, 2015-10-04)Purpose.: To analyze the release of two fluoroquinolones, ciprofloxacin and moxifloxacin, from conventional hydrogel (CH) and silicone hydrogel (SH) daily disposable contact lenses (CLs), comparing release from a fixed-volume ... -
Release of Moxifloxacin from Contact Lenses Using an In Vitro Eye Model: Impact of Artificial Tear Fluid Composition and Mechanical Rubbing
Phan, Chau-Minh; Bajgrowicz-Cieslak, Magdalena; Subbaraman, Lakshman N.; Jones, Lyndon W. (Association for Research in Vision and Ophthalmology, 2016-08-11)Purpose: The aim of this study was to evaluate and compare the release of moxifloxacin from a variety of daily disposable (DD) contact lenses (CLs) under various conditions using a novel in vitro eye model. Methods: Four ... -
Tear exchange and contact lenses: A review
Muntz, Alex; Subbaraman, Lakshman N.; Sorbara, Luigina; Jones, Lyndon W. (Elsevier, 2015-01)Tear exchange beneath a contact lens facilitates ongoing fluid replenishment between the ocular surface and the lens. This exchange is considerably lower during the wear of soft lenses compared with rigid lenses. As a ...