Browsing Science (Faculty of) by Subject "biophysics"
Now showing items 1-3 of 3
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A preclinical study of SG pseudopeptide amyloid-β inhibitors for the treatment of Alzheimer’s disease: single molecule force spectroscopy and cell viability
(University of Waterloo, 2017-08-23)Alzheimer's disease (AD) is one of the single greatest healthcare challenges facing our society today with no treatments available that cure, prevent or slow the disease. Neurodegeneration in AD is observed alongside ... -
Selected Experiments with Proteins at Solid-Liquid Interfaces
(University of Waterloo, 2008-12-12)This thesis describes a number of novel experiments contributing to the understanding of protein adsorption from both a fundamental and applied perspective. The first three papers involve the use of the localized surface ... -
Stability and Strain in Hisactophilin and Mechanism of the Myristoyl Switch
(University of Waterloo, 2019-05-23)Hisactophilin is a myristoylated, histidine-rich, pH-dependent actin- and membrane-binding protein. In response to cellular changes in pH, this β-trefoil protein reversibly switches between cytosolic and membrane- bound ...