Browsing Science (Faculty of) by Subject "bioinformatics"
Now showing items 1-8 of 8
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Bioinformatic insights into the diversity and evolution of bacterial toxins
(University of Waterloo, 2020-01-24)Bacterial toxins are a broad category of molecules ranging from small organic compounds and peptides to large multi-domain or multi-meric enzymes. Several important diseases are caused primarily by bacterial toxins including ... -
A Data Mining Approach for Detecting Evolutionary Divergence in Transcriptomic Data
(University of Waterloo, 2019-11-19)It has become common to produce genome sequences for organisms of scientific or popular interest. Although these genome projects provide insight into the gene and protein complements of a species including their evolutionary ... -
Discovering new viral lineages and estimating their abundance in wastewater
(University of Waterloo, 2022-09-27)Wastewater surveillance of SARS-CoV-2 has emerged as a critical tool for tracking the spread of COVID-19. In addition to estimating the relative case numbers using qPCR, SARS-CoV-2 genomic RNA can be extracted from wastewater ... -
Microbial Ecology of Phototrophs in Iron-rich Boreal Shield Lakes
(University of Waterloo, 2020-09-24)The early Earth oceans of the Archaean Eon (approx. 3.8-2.5 billion years ago) are thought to have been predominantly anoxic with ferruginous waters containing high levels of dissolved ferrous iron and low levels of sulfate. ... -
Micromeda: a genome property prediction pipeline and web visualization tool
(University of Waterloo, 2020-05-07)Understanding the distribution of biochemical pathways across microorganisms is critical to understanding these organism's evolution, ecology, and industrial applicability. Advances in genome sequencing and pathway databases ... -
The Proximon: Representation, Evaluation, and Applications of Metagenomic Functional Interactions
(University of Waterloo, 2017-09-19)The effective use of metagenomic functional interactions represents a key prospect for a variety of applications in the field of functional metagenomics. By definition, metagenomic operons represent such interactions but ... -
Sex differences in solute and water handling in the human kidney: Modeling and functional implications
(Elsevier, 2021-06)The kidneys maintain homeostasis by controlling the amount of water and electrolytes in the blood. That function is accomplished by the nephrons, which transform glomerular filtrate into urine by a transport process mediated ... -
Structure-aided detection of functional innovation in protein phylogenies
(University of Waterloo, 2016-01-19)Detection of positive selection in proteins is both a common and powerful approach for investigating the molecular basis of adaptation. In this thesis, I explore the use of protein three- dimensional (3D) structure to ...