Browsing Science (Faculty of) by Author "Hamilton, Mark Evan"
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The characterization of γH2AX and p53 as biomarkers of genotoxic stress in a rainbow trout (Oncorhynchus mykiss) brain cell line
Hamilton, Mark Evan; Bols, Niels C.; Duncker, Bernard P. (Elsevier, 2018-06-01)Rainbow trout cell cultures were exposed to three genotoxicants and examined for effects on γH2AX and p53 levels by western blotting and on cell viability using the indicator dyes Alamar Blue (AB) for energy metabolism and ... -
The characterization of γH2AX as a biomarker of genotoxicity in Oncorhynchus mykiss
Hamilton, Mark Evan (University of Waterloo, 2017-05-19)Environmental contamination due to by-products and waste from industrial activities is a growing universal concern, especially regarding the impact on water and the aquaculture industry. Conventional tests to diagnose ... -
VER-155008 induced Hsp70 proteins expression in fish cell cultures while impeding replication of two RNA viruses
Pham, Phuc Hoang; Sokeechand, Bibi S.H.; Hamilton, Mark Evan; Misk, Ehab; Jones, Ginny; Lee, Lucy E.J.; Lumsden, John S.; Bols, Niels C. (Elsevier, 2019-02-01)The heat-shock protein 70 (Hsp70) inhibitor, VER-155008 (VER), was explored as a potential antiviral agent for two RNA viruses important to fish aquaculture, viral hemorrhagic septicemia virus (VHSV) and infectious pancreatic ...