Browsing Science (Faculty of) by Author "Scott, Bradley"
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An Acyl-Linked Dimer of Daptomycin Is Strongly Inhibited by the Bacterial Cell Wall
Taylor, Robert; Scott, Bradley; Taylor, Scott D.; Palmer, Michael (American Chemical Society, 2017-03-28)The lipopeptide antibiotic daptomycin is active against Gram-positive pathogens. It permeabilizes bacterial cell membranes, which involves the formation of membrane-associated oligomers. We here studied a dimer of daptomycin ... -
Daptomycin: studies on its action mode and on bacterial resistance with model membranes
Scott, Bradley (University of Waterloo, 2016-05-16)Bacterial resistance to antibiotics is one of the most serious problems facing medicine today. Recently, reports have appeared describing bacteria that are resistant to daptomycin (dap), an important antibiotic used against ... -
Two successive calcium-dependent transitions mediate membrane binding and oligomerization of daptomycin and the related antibiotic A54145
Taylor, Robert; Butt, Khalida; Scott, Bradley; Zhang, TianHua; Muraih, Jawad K.; Mintzer, Evan; Taylor, Scott D.; Palmer, Michael (Elsevier, 2016-09)Daptomycin and A54145 are homologous lipopeptide antibiotics that permeabilize the cell membranes of Gram-positive bacteria. Membrane permeabilization depends on the presence of both phosphatidylglycerol (PG) and calcium, ...