• Case Studies with Mathematical Modeling of Free-radical Multi-component Bulk/Solution Polymerizations:Part 2 

  Dorschner, David; Jung, Woosung; Riahinezhad, Marzieh; Duever, Thomas; Penlidis, Alexander (Taylor & Francis, 2017)

  In Part 2 of this series of two extensive overviews of multi-component polymerization case studies, we again present mathematical modeling results with experimental confirmations. Part 2 represents a refinement and ...

• Simulation-based Design of Temperature-responsive Nematic Elastomers 

  Neufeld, Ryan Alexander Epp (University of Waterloo, 2017-06-16)

  Liquid crystal elastomers (LCEs) are a class of polymer networks which involve the incorporation of liquid crystal (LC) molecules into their polymer backbone or side chain. This results in anisotropy in their mechanical, ...

• Developing Control Strategies to Regulate Dissolved Oxygen Levels in a Biological Fermenter 

  Khan, Omar (University of Waterloo, 2017-06-16)

  Vaccine development comprises multiple stages, the first of which typically involves cultivating an organism in a microbial fermenter to produce a vaccine product. In order to ensure the optimal synthesis of the vaccine ...

• Manipulating the sleeping beauty mutase operon for the production of 1-propanol in engineered Escherichia coli 

  Srirangan, Kajan; Akawi, Lamees; Liu, Xuejia; Westbrook, Adam; Blondeel, Eric J. M.; Aucoin, Marc; Moo-Young, Murray; Chou, C. Perry (BioMed Central, 2013-09-28)

  Background: While most resources in biofuels were directed towards implementing bioethanol programs, 1-propanol has recently received attention as a promising alternative biofuel. Nevertheless, no microorganism has been ...

• Construction and analysis of a genetically tuneable lytic phage display system 

  Nicastro, Jessica; Sheldon, Katlyn; El-zarkout, Farah A.; Sokolenko, Stanislav; Aucoin, Marc; Slavcev, Roderick (Springer, 2013-09-01)

  The Bacteriophage lambda capsid protein gpD has been used extensively for fusion polypeptides that can be expressed from plasmids in Escherichia coli and remain soluble. In this study, a genetically controlled dual expression ...

• Critical assessment of influenza VLP production in Sf9 and HEK293 expression systems 

  Thompson, Christine M.; Petiot Emma; Mullick Alaka; Aucoin, Marc; Henry Olivier; Kamen, Amine A. (BioMed Central, 2015-05-16)

  Background: Each year, influenza is responsible for hundreds of thousand cases of illness and deaths worldwide. Due to the virus' fast mutation rate, the World Health Organization (WHO) is constantly on alert to rapidly ...

• Treating Cell Culture Media with UV Irradiation against Adventitious Agents: Minimal Impact on CHO Performance 

  Yen, Sandi; Sokolenko, Stanislav; Manocha, Bhavik; Blondeel, Eric J. M.; Aucoin, Marc; Patras, Ankit; Daynouri-Pancino, Farnaz; Sasges, Michael (Wiley, 2014-10-01)

  Sterility of cell culture media is an important concern in biotherapeutic processing. In large scale biotherapeutic production, a unit contamination of cell culture media can have costly effects. Ultraviolet (UV) irradiation ...

• Identifying model error in metabolic flux analysis - a generalized least squares approach 

  Sokolenko, Stanislav; Quattrociocchi, Marco; Aucoin, Marc (BioMed Central, 2016-09-13)

  Background: The estimation of intracellular flux through traditional metabolic flux analysis (MFA) using an overdetermined system of equations is a well established practice in metabolic engineering. Despite the continued ...

• A correction method for systematic error in 1H-NMR time-course data validated through stochastic cell culture simulation 

  Sokolenko, Stanislav; Aucoin, Marc (BioMed Central, 2015-09-04)

  Background: The growing ubiquity of metabolomic techniques has facilitated high frequency time-course data collection for an increasing number of applications. While the concentration trends of individual metabolites can ...

• Impact of dissolved oxygen during UV-irradiation on the chemical composition and function of CHO cell culture media 

  Meunier Sarah M.; Todorovic, Biljana; Dare, Emma V.; Begum, Afroza; Guillemette, Simon R.; Wenger, Andrew; Saxena, Priyanka; Campbell, J. Larry; Sasges, Michael; Aucoin, Marc (Public Library of Science, 2016-03-14)

  Ultraviolet (UV) irradiation is advantageous as a sterilization technique in the biopharmaceutical industry since it is capable of targeting non-enveloped viruses that are typically challenging to destroy, as well as smaller ...

• Utilizing ‘Power-to-Gas’ Technology for Storing Energy and to Optimize the Synergy between Environmental Obligations and Economical Requirements 

  Al Rafea, Kamal (University of Waterloo, 2017-06-05)

  This work develops a generalized modeling framework using several approaches for assessing the feasibility of storing energy in order to demonstrate the economic and environmental benefits of managing the existing power ...

• Hybrid Biocomposites with Starch Derived Nanoparticles and Cellulose Fibers 

  Khan, Injla (University of Waterloo, 2017-06-01)

  The use of natural polymers such as starch and cellulose in composites has gained significant popularity due to two main reasons: i) biopolymers increase the ratio of biodegradable and renewable content in most fossil-based ...

• Removal of N,N-dimethylacetamide from water by adsorption 

  Qiu, Bo (University of Waterloo, 2017-05-24)

  Discharge of untreated industrial effluents containing N,N-dimethylacetamide (DMAc) is hazardous to the environment. This study explores the separation of DMAc from wastewater using adsorption on activated carbons. In ...

• Catalytic Distillation: Modeling and Process Development for Fuels and Chemicals 

  Gaurav, Aashish (University of Waterloo, 2017-05-09)

  Catalytic Distillation (CD) is a hybrid green reactor technology that utilizes the dynamics of simultaneous reaction and separation in a single process unit to achieve a more compact, economical, efficient and optimized ...

• Nature-Inspired Polymers: Promising Materials for OTFT-Based Sensors 

  Quinn, Jesse (University of Waterloo, 2017-05-03)

  The concept of an organic thin film transistor was first introduced in the late 1980s and research was directed toward two key merits of performance, field-effect mobility and current ON/OFF ratio. Today these two key ...

• Sorptive separation of phenolic compounds from wastewater 

  Lai, Shuixiu (University of Waterloo, 2017-04-28)

  This study explores the potential of using PEBA as a sorbent for removing phenolic compounds from wastewater. The sorption isotherms of phenol, 4-chlorophenol (4-CP), 4-nitrophenol (4-NP), 4-methylphenol (4-MP) and catechol ...

• Optimal Integration of Renewable Energy Sources in Oil Refinery Operations 

  alnifro, mohamed (University of Waterloo, 2017-04-27)

  Petroleum refining is one of the energy intensive sectors of the oil and gas (O&G) industry. With increase in global energy demand and declining energy return on energy invested (EROEI) of crude oil, global energy consumption ...

• Improving Biocompatibility of Implantable Bioelectronics using Zwitterionic Cysteine 

  Lin, Peter (University of Waterloo, 2017-04-27)

  Recent advances in bioelectronics have allowed for faster diagnoses of diseases as well as treatments for disorders that were previously considered incurable. The performance of these devices is, however, severely hindered ...

• Modification of Recycled Poly(ethylene terephthalate) for FDM 3D-Printing Applications 

  Alzahrani, Mohammed (University of Waterloo, 2017-04-27)

  In this work, we have studied the suitability of recycled Poly(ethylene terephthalate) (R-PET) for 3D-pritning applications by studying the melt flow characteristics of the polymer. R-PET is known to experience a significant ...

• Effect of Milling on Electrostatic Separation and Modeling Protein and Starch Content of Flour Fractions 

  Vitelli, Michael (University of Waterloo, 2017-04-24)

  The objective of this research is to establish the effects of different milling techniques on the solvent-free electrostatic separation process for navy bean flour as well as to develop a model based on near infrared and ...

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