Browsing Engineering (Faculty of) by Author "Blondeel, Eric J. M."
Now showing items 1-4 of 4
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Manipulating the sleeping beauty mutase operon for the production of 1-propanol in engineered Escherichia coli
Srirangan, Kajan; Akawi, Lamees; Liu, Xuejia; Westbrook, Adam; Blondeel, Eric J. M.; Aucoin, Marc; Moo-Young, Murray; Chou, C. Perry (BioMed Central, 2013-09-28)Background: While most resources in biofuels were directed towards implementing bioethanol programs, 1-propanol has recently received attention as a promising alternative biofuel. Nevertheless, no microorganism has been ... -
Supplementation Strategies for Tuning Glycosylation of Monoclonal Antibodies and Enhancing Growth in Mammalian Cell Culture by Omics Analysis
Blondeel, Eric (University of Waterloo, 2018-04-17)Two fundamental objectives of bioprocess engineering are to increase productivity and improve product quality. Glycosylation is a critical and variable factor in the quality of several therapeutic proteins, particularly ... -
Supplementing glycosylation: A review of applying nucleotide-sugar precursors to growth medium to affect therapeutic recombinant protein glycoform distributions
Blondeel, Eric J. M.; Aucoin, Marc (Elsevier, 2018-09-01)Glycosylation is a critical quality attribute (CQA) of many therapeutic proteins, particularly monoclonal antibodies (mAbs), and is a major consideration in the approval of biosimilar biologics due to its effects to ... -
Treating Cell Culture Media with UV Irradiation against Adventitious Agents: Minimal Impact on CHO Performance
Yen, Sandi; Sokolenko, Stanislav; Manocha, Bhavik; Blondeel, Eric J. M.; Aucoin, Marc; Patras, Ankit; Daynouri-Pancino, Farnaz; Sasges, Michael (Wiley, 2014-10-01)Sterility of cell culture media is an important concern in biotherapeutic processing. In large scale biotherapeutic production, a unit contamination of cell culture media can have costly effects. Ultraviolet (UV) irradiation ...