dc.contributor.author | Legros, Camille | |
dc.date.accessioned | 2015-01-27 20:13:55 (GMT) | |
dc.date.available | 2015-01-27 20:13:55 (GMT) | |
dc.date.issued | 2015-01-27 | |
dc.date.submitted | 2014 | |
dc.identifier.uri | http://hdl.handle.net/10012/9154 | |
dc.description.abstract | This PhD work is based on the design of poly(2-oxazoline) (POx) hydrogels and nanogels, by chemical or physical cross-linking, aimed to be used for biomedical applications. Nanogels were first prepared in dilute media and in inverse emulsion based on a statistical copolymer made of 2-ethyl-2-oxazoline and ethylene imine units. These stimuli-responsive nanogels were swelling in acidic media and were cleaved in reductive environment. They proved to be non-cytotoxic and act as protein repellent. Second, a reactive platform based on a statistical POx polymer bearing aldehyde functionalities was engineered, enabling the synthesis of graft and cross-linked POx. Last, a block copolymer made of 2-methyl- and 2-isopropyl-2-oxazoline units, proved to self-assemble into micelles when heated above its LCST, for a short period of time (< 1h30). When annealed for a longer time (> 1h30), crystallization-driven self-assembly led to the formation of different morphologies (fiber rods and cross-linked micelles). | en |
dc.language.iso | en | en |
dc.publisher | University of Waterloo | en |
dc.subject | poly(2-oxazoline) | en |
dc.subject | nanogel | en |
dc.subject | hydrogel | en |
dc.subject | responsive | en |
dc.subject | crystallization | en |
dc.subject | LCST | en |
dc.subject | post-polymerization modification | en |
dc.subject | aldehyde | en |
dc.subject | cytotoxicity | en |
dc.subject | protein repellent | en |
dc.title | Engineering of poly(2-oxazoline)s for a potential use in biomedical applications | en |
dc.type | Doctoral Thesis | en |
dc.pending | false | |
dc.subject.program | Chemical Engineering | en |
uws-etd.degree.department | Chemical Engineering | en |
uws-etd.degree | Doctor of Philosophy | en |
uws.typeOfResource | Text | en |
uws.peerReviewStatus | Unreviewed | en |
uws.scholarLevel | Graduate | en |