Browsing Theses by Subject "enzymology"
Now showing items 1-2 of 2
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Biochemical and Biophysical Investigations of Non-Zinc Dependent Glyoxalase I Enzymes
(University of Waterloo, 2008-09-26)The principal methylglyoxal (MG)-detoxifying system in most living organisms is the two metalloenzyme Glyoxalase system. Glyoxalase I (GlxI) initially converts the non-enzymatically formed MG-GSH hemithioacetal to the ... -
Investigations of the Natural Product Antibiotic Thiostrepton from Streptomyces azureus and Associated Mechanisms of Resistance
(University of Waterloo, 2013-03-11)The persistence and propagation of bacterial antibiotic resistance presents significant challenges to the treatment of drug resistant bacteria with current antimicrobial chemotherapies, while a dearth in replacements for ...