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dc.contributor.authorZorzitto, Alexander
dc.date.accessioned2009-08-27 19:53:26 (GMT)
dc.date.available2009-08-27 19:53:26 (GMT)
dc.date.issued2009-08-27T19:53:26Z
dc.date.submitted2009-08-10
dc.identifier.urihttp://hdl.handle.net/10012/4629
dc.description.abstractThe Rh-catalyzed conjugate addition of TMS-acetylene to alkylidene Meldrum’s acids was developed. Exceptional ee’s and yields were attained using chiral 3,5-Xylyl-BIPHEP ligand. The scope of the reaction was also shown to be very broad with functionalities including phenol, silyl ether, and boronates being tolerated. The successful deprotection and subsequent Sonogashira coupling reaction of the terminal alkyne was also developed.en
dc.language.isoenen
dc.publisherUniversity of Waterlooen
dc.titleEnantioselective Rh(I)-Catalyzed Conjugate Alkynylation of 5-Benzylidene Meldrum’s Acid with TMS-acetyleneen
dc.typeMaster Thesisen
dc.pendingfalseen
dc.subject.programChemistryen
uws-etd.degree.departmentChemistryen
uws-etd.degreeMaster of Scienceen
uws.typeOfResourceTexten
uws.peerReviewStatusUnrevieweden
uws.scholarLevelGraduateen


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