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Microfluidic Viscometer for Tear Films and Other Biofluids

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Kapadia_Wasim.pdf (2.14 MB)

Date

2022-08-26

Authors

Kapadia, Wasim

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Publisher

University of Waterloo

Abstract

A microfluidic viscometer platform is developed and validated for measuring microliter-volume liquid samples, such as human tear films. The microfluidic viscometer combines an optically clear acrylic chip with a hydrophobic surface coating together with a syringe pump to control the sample flow rate. Additional functionally supporting devices, including a camera and a differential pressure transducer, were used for analysis. It has been demonstrated that the microfluidic viscometer could measure the viscosities of both Newtonian and non-Newtonian liquid samples, and their relevant calculations are presented. The microfluidic viscometer has potential applications in measuring the rheological properties of biofluids for diagnostic applications.

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Keywords

microfluidic viscometer, tear films, microfluidic rheometer, viscosity, dry eye disease

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Citation

URI

http://hdl.handle.net/10012/18650

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Theses
Mechanical and Mechatronics Engineering