Towards principled design of cancer nanomedicine to accelerate clinical translation
Loading...
Date
2022-01
Authors
Souri, Mohammad
Soltani, M.
Kashkooli, Farshad Moradi
Shahvandi, Mohammad Kiani
Chiani, Mohsen
Shariati, Fatemeh Sadat
Mehrabi, Mohammad Reza
Munn, Lance L.
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Nanotechnology in medical applications, especially in oncology as drug delivery systems, has recently shown promising results. However, although these advances have been promising in the pre-clinical stages, the clinical translation of this technology is challenging. To create drug delivery systems with increased treatment efficacy for clinical translation, the physicochemical characteristics of nanoparticles such as size, shape, elasticity (flexibility/rigidity), surface chemistry, and surface charge can be specified to optimize efficiency for a given application. Consequently, interdisciplinary researchers have focused on producing biocompatible materials, production technologies, or new formulations for efficient loading, and high stability. The effects of design parameters can be studied in vitro, in vivo, or using computational models, with the goal of understanding how they affect nanoparticle biophysics and their interactions with cells. The present review summarizes the advances and technologies in the production and design of cancer nanomedicines to achieve clinical translation and commercialization. We also highlight existing challenges and opportunities in the field.
Description
Keywords
tumor microenvironment, nanomedicine, drug delivery, nanoparticle design, drug loading, clinical translation