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dc.contributor.authorMa, Lingzi
dc.contributor.authorLiu, Juewen
dc.date.accessioned2022-01-31 21:40:28 (GMT)
dc.date.available2022-01-31 21:40:28 (GMT)
dc.date.issued2020-01
dc.identifier.urihttps://doi.org/10.1016/j.isci.2019.100815
dc.identifier.urihttp://hdl.handle.net/10012/18020
dc.description.abstractSince the initial discovery of ribozymes in the early 1980s, catalytic nucleic acids have been used in different areas. Compared with protein enzymes, catalytic nucleic acids are programmable in structure, easy to modify, and more stable especially for DNA. We take a historic view to summarize a few main interdisciplinary areas of research on nucleic acid enzymes that may have broader impacts. Early efforts on ribozymes in the 1980s have broken the notion that all enzymes are proteins, supplying new evidence for the RNA world hypothesis. In 1994, the first catalytic DNA (DNAzyme) was reported. Since 2000, the biosensor applications of DNAzymes have emerged and DNAzymes are particularly useful for detecting metal ions, a challenging task for enzymes and antibodies. Combined with nanotechnology, DNAzymes are key building elements for switches allowing dynamic control of materials assembly. The search for new DNAzymes and ribozymes is facilitated by developments in DNA sequencing and computational algorithms, further broadening our fundamental understanding of their biochemistry.en
dc.description.sponsorshipNatural Sciences and Engineering Research Council of Canadaen
dc.language.isoenen
dc.publisherElsevieren
dc.relation.ispartofseriesiScience;
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectchemistryen
dc.subjectbiochemistryen
dc.subjectbiochemistry applicationsen
dc.subjectenzymologyen
dc.subjectbiomoleculesen
dc.subjectnanotechnologyen
dc.titleCatalytic Nucleic Acids: Biochemistry, Chemical Biology, Biosensors, and Nanotechnologyen
dc.typeArticleen
dcterms.bibliographicCitationMa, L., & Liu, J. (2020). Catalytic Nucleic Acids: Biochemistry, Chemical Biology, Biosensors, and Nanotechnology. IScience, 23(1), 100815. https://doi.org/10.1016/j.isci.2019.100815en
uws.contributor.affiliation1Faculty of Engineeringen
uws.contributor.affiliation1Faculty of Scienceen
uws.contributor.affiliation2Chemical Engineeringen
uws.contributor.affiliation2Waterloo Institute for Nanotechnology (WIN)en
uws.typeOfResourceTexten
uws.peerReviewStatusRevieweden
uws.scholarLevelFacultyen
uws.scholarLevelPost-Doctorateen


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