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dc.contributor.authorBrown, Ronald B.
dc.date.accessioned2020-06-23 16:34:09 (GMT)
dc.date.available2020-06-23 16:34:09 (GMT)
dc.date.issued2019-02-11
dc.identifier.urihttps://doi.org/10.3390/dj7010018
dc.identifier.urihttp://hdl.handle.net/10012/16010
dc.description.abstractAn association between periodontal disease and cancer has been established in recent studies, but no common etiology has been identified in the hopes of reducing the global burden of these non-communicable diseases. This perspective article hypothesizes that the determinant mediating the association of periodontal disease with cancer is dysregulated phosphate metabolism. Phosphate, an essential dietary micronutrient, is dysregulated in chronic kidney disease, and both cancer and periodontal disease are associated with chronic kidney disease. Reviewed evidence includes the association between phosphate toxicity and cancer development, and the association between periodontal disease and chronic kidney disease-mineral and bone disorder includes conditions such as ectopic calcification and bone resorption, which may be indirectly related to periodontal disease. Dental calculus in periodontal disease contains calcium phosphate crystals that are deposited from excess calcium and phosphate in saliva. Alveolar bone resorption may be linked systemically to release of parathyroid hormone in response to hypocalcemia induced by hyperphosphatemia. More research is needed to examine the role of dysregulated phosphate metabolism in periodontal disease.en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectphosphate toxicityen
dc.subjectperiodontal diseaseen
dc.subjectcanceren
dc.subjecttumorigenesisen
dc.subjectchronic kidney diseaseen
dc.subjectmineral and bone disorderen
dc.subjectdental calculusen
dc.subjectresorptionen
dc.subjectRNAen
dc.subjectglobal healthen
dc.subjectectopic calcificationen
dc.titleDysregulated Phosphate Metabolism, Periodontal Disease, and Cancer: Possible Global Health Implicationsen
dc.typeArticleen
dcterms.bibliographicCitationBrown, R.B. Dysregulated Phosphate Metabolism, Periodontal Disease, and Cancer: Possible Global Health Implications. Dent. J. 2019, 7, 18.en
uws.contributor.affiliation1Faculty of Applied Health Sciencesen
uws.contributor.affiliation2Public Health and Health Systems (School of)en
uws.typeOfResourceTexten
uws.peerReviewStatusRevieweden
uws.scholarLevelGraduateen


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