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dc.contributor.authorHuh, Haein
dc.contributor.authorWong, Shirley
dc.contributor.authorSt. Jean, Jesse
dc.contributor.authorSlavcev, Roderick
dc.date.accessioned2020-03-19 16:13:16 (GMT)
dc.date.available2020-03-19 16:13:16 (GMT)
dc.date.issued2019-05
dc.identifier.urihttps://doi.org/10.1016/j.addr.2019.01.003
dc.identifier.urihttp://hdl.handle.net/10012/15708
dc.description.abstractThe human body is a large reservoir for bacterial viruses known as bacteriophages (phages), which participate in dynamic interactions with their bacterial and human hosts that ultimately affect human health. The current growing interest in human resident phages is paralleled by new uses of phages, including the design of engineered phages for therapeutic applications. Despite the increasing number of clinical trials being conducted, the understanding of the interaction of phages and mammalian cells and tissues is still largely unknown. The presence of phages in compartments within the body previously considered purely sterile, suggests that phages possess a unique capability of bypassing anatomical and physiological barriers characterized by varying degrees of selectivity and permeability. This review will discuss the direct evidence of the accumulation of bacteriophages in various tissues, focusing on the unique capability of phages to traverse relatively impermeable barriers in mammals and its relevance to its current applications in therapy.en
dc.language.isoenen
dc.publisherElsevieren
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectbacteriophageen
dc.subjectvirusen
dc.subjectmicrobiomeen
dc.subjectgastrointestinalen
dc.subjectblood-brain barrieren
dc.subjectgastrointestinal tracten
dc.subjectrespiratory tracten
dc.subjectendotheliumen
dc.subjectepitheliumen
dc.subjectdermisen
dc.titleBacteriophage interactions with mammalian tissue: Therapeutic applicationsen
dc.typeArticleen
dcterms.bibliographicCitationHuh, Haein, Shirley Wong, Jesse St. Jean, and Roderick Slavcev. “Bacteriophage Interactions with Mammalian Tissue: Therapeutic Applications.” Advanced Drug Delivery Reviews, Biomaterials based on phages and other viruses, 145 (May 1, 2019): 4–17. https://doi.org/10.1016/j.addr.2019.01.003.en
uws.contributor.affiliation1Faculty of Scienceen
uws.contributor.affiliation2School of Pharmacyen
uws.typeOfResourceTexten
uws.peerReviewStatusRevieweden
uws.scholarLevelFacultyen
uws.scholarLevelGraduateen


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