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dc.contributor.authorGorbet, Maud
dc.contributor.authorSperling, Claudia
dc.contributor.authorMaitz, Manfred
dc.contributor.authorSiedleck, Christopher A.
dc.contributor.authorWerner, Carsten
dc.contributor.authorSefton, Michael V. 18:54:27 (GMT) 18:54:27 (GMT)
dc.descriptionThe final publication is available at Elsevier via © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
dc.description.abstractFollowing protein adsorption/activation which is the first step after the contact of material surfaces and whole blood (part 2), fibrinogen is converted to fibrin and platelets become activated and assembled in the form of a thrombus. This thrombus formation is the key feature that needs to be minimized in the creation of materials with low thrombogenicity. Further aspects of blood compatibility that are important on their own are complement and leukocyte activation which are also important drivers of thrombus formation. Hence this review summarizes the state of knowledge on all of these cascades and cells and their interactions. For each cascade or cell type, the chapter distinguishes statements which are in widespread agreement from statements where there is less of a consensus.en
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.subjectblood compatibilityen
dc.subjectcoagulation cascadeen
dc.subjectplatelet activationen
dc.subjectleukocyte activationen
dc.titleThe blood compatibility challenge. Part 3: Material associated activation of blood cascades and cellsen
dcterms.bibliographicCitationGorbet, M., Sperling, C., Maitz, M.F., Siedleck, C.A., Werner, C., Sefton, M.V., The blood compatibility challenge Part 3: Material associated activation of blood cascades and cells, Acta Biomaterialia (2019), doi:
uws.contributor.affiliation1Faculty of Engineeringen
uws.contributor.affiliation1Faculty of Scienceen
uws.contributor.affiliation2School of Optometry and Vision Scienceen
uws.contributor.affiliation2Systems Design Engineeringen

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