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dc.contributor.authorParichehreh, Roya
dc.contributor.authorGheshlaghi, Reza
dc.contributor.authorMahdavi, Mahmood Akhavan
dc.contributor.authorElkamel, Ali
dc.date.accessioned2018-11-14 16:43:26 (GMT)
dc.date.available2018-11-14 16:43:26 (GMT)
dc.date.issued2019-01-15
dc.identifier.urihttps://dx.doi.org/10.1016/j.bej.2018.10.011
dc.identifier.urihttp://hdl.handle.net/10012/14119
dc.descriptionThe final publication is available at Elsevier via https://dx.doi.org/10.1016/j.bej.2018.10.011 © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.description.abstractMicroalgae, the world’s largest group of photosynthetic organisms, convert atmospheric CO2 to polar and neutral lipids using sunlight, which after esterification can be utilized for biodiesel production. In the present study, a fully compartmentalized metabolic network was developed to describe the metabolism of Chlorella vulgaris based on known enzymatic reactions and typical metabolic pathways of green algae. Flux balance analysis was employed to optimize the specific growth rate and the lipid production rate using measured exchange fluxes of the metabolites. The experimental data for batch and fed batch algal fermentation systems acquired from the literature were used to validate the accuracy of the pseudo- steady state model. The physiological pathways of the microalgae for lipid biosynthesis were identified. The simulation revealed that the microalgae would be able to produce higher levels of lipid content (43.6%) during N-starvation cultivation under 100 μmol m−2 s−1 light intensity, 0.25 vvm aeration with 2% (v/v) CO2, 2 mg L−1 PO4-P, and 5 mg L−1 NO3-N. Sensitivity analysis showed that CO2, light energy, O2, and nitrate were the most important factors affecting the lipid production at N-deficient conditions. The findings consequential for manipulation of the metabolism of the microalgae with optimal activity.en
dc.description.sponsorshipFerdowsi university of Mashhad’s research center, Iran ["25902"]]en
dc.language.isoenen
dc.publisherElsevieren
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectSensitivity analysisen
dc.subjectBiodieselen
dc.subjectCarbon utilizationen
dc.subjectFlux balance analysisen
dc.subjectLipid optimizationen
dc.titleOptimization of lipid production in Chlorella vulgaris for biodiesel production using flux balance analysisen
dc.typeArticleen
dcterms.bibliographicCitationParichehreh, R., Gheshlaghi, R., Mahdavi, M. A., & Elkamel, A. (2019). Optimization of lipid production in Chlorella vulgaris for biodiesel production using flux balance analysis. Biochemical Engineering Journal, 141, 131–145. doi:10.1016/j.bej.2018.10.011en
uws.contributor.affiliation1Faculty of Engineeringen
uws.contributor.affiliation2Chemical Engineeringen
uws.typeOfResourceTexten
uws.typeOfResourceTexten
uws.peerReviewStatusRevieweden
uws.scholarLevelFacultyen


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