Show simple item record

dc.contributor.authorLamontagne-Kam, Daniel M.
dc.contributor.authorChalil, Alan
dc.contributor.authorAristizabal Henao, Juan Jose
dc.contributor.authorHogenhout, Sam J.
dc.contributor.authorStark, Ken
dc.date.accessioned2018-11-06 18:08:49 (GMT)
dc.date.available2018-11-06 18:08:49 (GMT)
dc.date.issued2018-11-01
dc.identifier.urihttps://dx.doi.org/10.1016/j.plefa.2018.10.003
dc.identifier.urihttp://hdl.handle.net/10012/14101
dc.descriptionThe final publication is available at Elsevier via https://dx.doi.org/10.1016/j.plefa.2018.10.003 © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.description.abstractFetal accretion for DHA is high during late pregnancy due to the brain growth spurt. Prior evidence suggests that DHA is mobilized from maternal liver and adipose to meet fetal accretion and physiological requirements. However, changes in the DHA levels of various maternal tissues throughout pregnancy and into lactation of mothers on diets with and without dietary DHA, and with a background dietary fatty acid profile that resembles human intake has not been examined. Sprague Dawley rats were fed a total western diet with (TWD + ) or without DHA (TWD-) along with a commercial rodent chow control (Chow) throughout pregnancy and postpartum. The fatty acid compositions of adipose, brain, heart, liver, erythrocytes, and plasma were determined before pregnancy, at 15 and 20 days of pregnancy, and 7 days postpartum. The placenta, fetuses, and pups were also examined when available. Maternal DHA concentrations were increased in plasma at 20 days pregnancy in all the diets with TWD + > Chow > TWD-. Maternal DHA concentrations in the TWD- group were lower in adipose throughout pregnancy as compared with the other diets. At postpartum, DHA concentrations decreased below baseline levels in the heart of the TWD- and Chow dams and the liver of the TWD- dams. Whole body DHA concentrations of the fetuses did not differ but there was evidence of decreased DHA in the whole body and tissues of the TWD- and Chow 7d old pups. In conclusion, it appears that in this rodent model of pregnancy, maternal adaptations were made to meet fetal DHA requirements, but they may compromise maternal DHA status and the ability to deliver DHA during lactation.en
dc.description.sponsorshipNatural Sciences and Engineering Research Council of Canada [327149-2013]en
dc.description.sponsorshipCanada Research Chairs program as a Chair in Nutritional Lipidomics [950-228125]en
dc.language.isoenen
dc.publisherElsevieren
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectOmega-3en
dc.subjectALAen
dc.subjectARAen
dc.subjectBHTen
dc.subjectDHAen
dc.subjectDocosahexaenoic aciden
dc.subjectDPAen
dc.subjectEPAen
dc.subjectFatty acid compositionen
dc.subjectFetusen
dc.subjectHearten
dc.subjectInfanten
dc.subjectLAen
dc.subjectLactationen
dc.subjectLCen
dc.subjectMUFAen
dc.subjectPlasmaen
dc.subjectPostpartumen
dc.subjectPregnancyen
dc.subjectPUFAen
dc.subjectPupen
dc.subjectSFAen
dc.titleConcentrations of docosahexaenoic acid are reduced in maternal liver, adipose, and heart in rats fed high-fat diets without docosahexaenoic acid throughout pregnancyen
dc.typeArticleen
dcterms.bibliographicCitationLamontagne-Kam, D. M., Chalil, A., Aristizabal Henao, J. J., Hogenhout, S. J., & Stark, K. D. (2018). Concentrations of docosahexaenoic acid are reduced in maternal liver, adipose, and heart in rats fed high-fat diets without docosahexaenoic acid throughout pregnancy. Prostaglandins, Leukotrienes and Essential Fatty Acids, 138, 30–37. doi:10.1016/j.plefa.2018.10.003en
uws.contributor.affiliation1Faculty of Applied Health Sciencesen
uws.contributor.affiliation2Kinesiologyen
uws.typeOfResourceTexten
uws.typeOfResourceTexten
uws.peerReviewStatusRevieweden
uws.scholarLevelFacultyen


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International

UWSpace

University of Waterloo Library
200 University Avenue West
Waterloo, Ontario, Canada N2L 3G1
519 888 4883

All items in UWSpace are protected by copyright, with all rights reserved.

DSpace software

Service outages