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dc.contributor.authorBarati, Nastaran
dc.contributor.authorRazazan, Atefeh
dc.contributor.authorNicastro, Jessica
dc.contributor.authorSlavcev, Roderick
dc.contributor.authorArab, Atefeh
dc.contributor.authorMosaffa, Fatemeh
dc.contributor.authorNikpoor, Amin Reza
dc.contributor.authorBadiee, Ali
dc.contributor.authorJaafari, Mahmoud Reza
dc.contributor.authorBehravan, Javad 13:37:10 (GMT) 13:37:10 (GMT)
dc.descriptionThe final publication is available at Elsevier via © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
dc.description.abstractPhage display technique has been increasingly researched for vaccine design and delivery strategies in recent years. In this study, the AE37 (Ii-Key/HER-2/neu 776–790) peptide derived from HER2 (human epidermal growth factor receptor protein) was used as a fused peptide to the lambda phage (λF7) coat protein gpD, and the phage nanoparticles were used to induce antitumor immunogenicity in a TUBO model of breast cancer in mice. Mice were immunized with the AE37 peptide displaying phage, λF7 (gpD::AE37) every 2-week intervals over 6-weeks, then the generated immune responses were evaluated. An induction of CTL immune response by the λF7 (gpD::AE37) construct compared to the control λF7 and buffer groups was observed in vitro. Moreover, in the in vivo studies, the vaccine candidate showed promising prophylactic and therapeutic effects against the HER2 overexpressing cancer in BALB/c mice.en
dc.description.sponsorshipMashhad University of Medical Sciences, Mashhad, Iran bach (MUMS GN: 922610)en
dc.description.sponsorshipNSERC, Canada (NSERC GN: 214684)en
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.subjectAntitumor immunogenicityen
dc.subjectBecteriophage λF7en
dc.subjectBreast canceren
dc.titleImmunogenicity and antitumor activity of the superlytic λF7 phage nanoparticles displaying a HER2/neu-derived peptide AE37 in a tumor model of BALB/c miceen
dcterms.bibliographicCitationBarati, N., Razazan, A., Nicastro, J., Slavcev, R., Arab, A., Mosaffa, F., … Behravan, J. (2018). Immunogenicity and antitumor activity of the superlytic λF7 phage nanoparticles displaying a HER2/neu-derived peptide AE37 in a tumor model of BALB/c mice. Cancer Letters, 424, 109–116.
uws.contributor.affiliation1Faculty of Scienceen
uws.contributor.affiliation3Waterloo Institute for Nanotechnology (WIN)en

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