dc.contributor.author | Traore, Yannick L. | |
dc.contributor.author | Fumakia, Miral | |
dc.contributor.author | Gu, Jijin | |
dc.contributor.author | Ho, Emmanuel A. | |
dc.date.accessioned | 2018-05-09 14:03:58 (GMT) | |
dc.date.available | 2018-05-09 14:03:58 (GMT) | |
dc.date.issued | 2018-03-01 | |
dc.identifier.uri | https://doi.org/10.1177/0885328217739451 | |
dc.identifier.uri | http://hdl.handle.net/10012/13260 | |
dc.description | Traore, Y. L., Fumakia, M., Gu, J., & Ho, E. A. Dynamic mechanical behaviour of nanoparticle loaded biodegradable PVA films for vaginal drug delivery, Journal of Biomaterials Applications 32(8) pp. 1119–1126. Copyright © 2018 The Authors. Reprinted by permission of SAGE Publications. https://doi.org/10.1177/0885328217739451 | en |
dc.description.abstract | In this study, we investigated the viscoelastic and mechanical behaviour of polyvinyl alcohol films formulated along with carrageenan, plasticizing agents (polyethylene glycol and glycerol), and when loaded with nanoparticles as a model for potential applications as microbicides. The storage modulus, loss modulus and glass transition temperature were determined using a dynamic mechanical analyzer. Films fabricated from 2% to 5% polyvinyl alcohol containing 3 mg or 5 mg of fluorescently labeled nanoparticles were evaluated. The storage modulus and loss modulus values of blank films were shown to be higher than the nanoparticle-loaded films. Glass transition temperature determined using the storage modulus, and loss modulus was between 40–50℃ and 35–40℃, respectively. The tensile properties evaluated showed that 2% polyvinyl alcohol films were more elastic but less resistant to breaking compared to 5% polyvinyl alcohol films (2% films break around 1 N load and 5% films break around 7 N load). To our knowledge, this is the first study to evaluate the influence of nanoparticle and film composition on the physico-mechanical properties of polymeric films for vaginal drug delivery. | en |
dc.description.sponsorship | Natural Science and Engineering Research Council of Canada (NSERC) Discovery grant (Grant No.: RGPIN-2015-06008)
Research Manitoba Operating Grant and a Canada Foundation for Innovation (CFI) Leaders Opportunity Fund
Leslie F Buggey Professorship
Manitoba Graduate Scholarship from the province of Manitoba | en |
dc.language.iso | en | en |
dc.publisher | Sage Publishing | en |
dc.subject | Poly (vinyl alcohol) | en |
dc.subject | nanoparticles | en |
dc.subject | dynamic mechanical analysis | en |
dc.subject | modulus | en |
dc.subject | glass transition temperature | en |
dc.subject | thermal stability | en |
dc.title | Dynamic mechanical behaviour of nanoparticle loaded biodegradable PVA films for vaginal drug delivery | en |
dc.type | Article | en |
dcterms.bibliographicCitation | Traore, Y. L., Fumakia, M., Gu, J., & Ho, E. A. (2018). Dynamic mechanical behaviour of nanoparticle loaded biodegradable PVA films for vaginal drug delivery. Journal of Biomaterials Applications, 32(8), 1119–1126. https://doi.org/10.1177/0885328217739451 | en |
uws.contributor.affiliation1 | Faculty of Science | en |
uws.contributor.affiliation2 | School of Pharmacy | en |
uws.typeOfResource | Text | en |
uws.peerReviewStatus | Reviewed | en |
uws.scholarLevel | Faculty | en |